ICAM-1 supports adhesion of human small-cell lung carcinoma to endothelial cells

Adhesion of tumor cells to endothelium via cell-adhesion molecules constitutes a crucial step in metastasis, which is largely responsible for the poor prognosis of small-cell lung carcinoma (SCLC). Patients with SCLC were reported to have elevated levels of intercellular adhesion molecule-1 (ICAM-1)...

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Bibliographic Details
Published in:Clinical & experimental metastasis 2004-01, Vol.21 (3), p.185-189
Main Authors: Finzel, Angela H, Reininger, Armin J, Bode, Patrick A, Wurzinger, Laurenz J
Format: Article
Language:English
Subjects:
Carcinoma, Small Cell - pathology
Cell Adhesion - physiology
Cell Line, Tumor
Cells, Cultured
Endothelium, Vascular - cytology
Humans
Immunohistochemistry
Intercellular Adhesion Molecule-1 - physiology
Interleukin-1 - pharmacology
Lung Neoplasms - pathology
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Summary:Adhesion of tumor cells to endothelium via cell-adhesion molecules constitutes a crucial step in metastasis, which is largely responsible for the poor prognosis of small-cell lung carcinoma (SCLC). Patients with SCLC were reported to have elevated levels of intercellular adhesion molecule-1 (ICAM-1). The present study therefore focusses on endothelial ICAM-1 in tumor-cell adhesion. We found that the adherence of SCLC cells (cell lines H24, H69, H82) to cultured vascular endothelium in stasis and flow depends on the expression of ICAM-1. After blocking endothelial ICAM-1 with monoclonal antibodies, adhesion was significantly reduced. These results pinpoint ICAM-1 for the first time as a molecule crucially involved in SCLC cell-endothelial adhesion.
ISSN:0262-0898
1573-7276
DOI:10.1023/B:CLIN.0000037696.36108.27