Atypical multifocal ERG responses in patients with diseases affecting the photoreceptors

The purpose of this study was to investigate atypical multifocal ERG (mfERG) responses for patients with diseases that can affect the photoreceptors. MfERGS were obtained from seven patients with retinitis pigmentosa (RP), three with progressive cone dystrophy (CD) and eight with diabetic retinopath...

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Bibliographic Details
Published in:Vision research (Oxford) 2004-11, Vol.44 (25), p.2867-2874
Main Authors: Greenstein, V.C., Holopigian, K., Seiple, W., Carr, R.E., Hood, D.C.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cone dystrophy
Diabetic retinopathy
Diabetic Retinopathy - physiopathology
Electroretinogram
Electroretinography - methods
Female
Humans
Male
Medical sciences
Middle Aged
Ophthalmology
Photoreceptor Cells, Vertebrate - physiology
Retinal Degeneration - physiopathology
Retinal Diseases - physiopathology
Retinitis pigmentosa
Retinitis Pigmentosa - physiopathology
Retinopathies
Visual Fields
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Summary:The purpose of this study was to investigate atypical multifocal ERG (mfERG) responses for patients with diseases that can affect the photoreceptors. MfERGS were obtained from seven patients with retinitis pigmentosa (RP), three with progressive cone dystrophy (CD) and eight with diabetic retinopathy (DR). Both first- and second-order kernel responses were analyzed. The amplitudes and implicit times of the first-order responses were compared to those obtained from age-similar controls. For the first slice of the second-order response, the root-mean-square (RMS) and the signal-to-noise ratio (SNR) of each response were calculated. Achromatic visual fields were also obtained from each subject. For the three groups of patients, first-order responses with relatively large amplitudes, broad-shaped waveforms and markedly increased implicit times had non-measurable second-order responses. These responses were associated with areas of decreased visual field sensitivity. As RP, CD and DR affect the outer retina, the results are consistent with damage to the outer plexiform layer rather than damage to the inner retina.
ISSN:0042-6989
1878-5646
DOI:10.1016/j.visres.2004.06.020