Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides

Analysis of the exon–intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significant...

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Bibliographic Details
Published in:FEBS letters 2004-09, Vol.575 (1), p.109-111
Main Authors: Tordai, Hedvig, Patthy, László
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Exon–intron structure
Humans
Intron insertion
Introns
Molecular Sequence Data
Protein Sorting Signals - genetics
Proto-splice site
RNA Splice Sites
RNA Splicing
Signal peptide
Spliceosomes - genetics
Spliceosomes - metabolism
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Summary:Analysis of the exon–intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2004.08.045