Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: Preferential reduction in elevated serum triglyceride level

• Published in: Journal of Nutritional Science and Vitaminology 2004, Vol.50(3), pp.211-218
• Main Authors: Miwa, Y. (Hayashibara Biochemical Labs. Inc., Okayama (Japan)), Yamada, M, Sunayama, T, Mitsuzumi, H, Tsuzaki, Y, Chaen, H, Mishima, Y, Kibata, M
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein C-II; Apolipoproteins B - blood; Apolipoproteins C - blood; Apolipoproteins E - blood; Biological and medical sciences; CHOLESTEROL; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Feeding. Feeding behavior; FLAVONOIDS; Fundamental and applied biological sciences. Psychology; GLUCOSIDES; Glucosides - administration & dosage; Hesperidin - administration & dosage; Hesperidin - analogs & derivatives; Humans; Hyperlipidemias - drug therapy; Lipids - blood; LIPOPROTEINS; Male; Middle Aged; Particle Size; TRIGLYCERIDES; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.50.211

Although hesperidin lowers serum total cholesterol (TC) or triglyceride (TG) in animal models, its effect in humans remains unclear. Using a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), as a hesperidin source, we examined the efficacy on hyperlipidemic subjects. G-Hesperidin was administered to the subjects at 100 or 500mg/d for 6 wk. The percentage of subjects who had a change in serum cholesterol levels was less than 20%. However, 45-55% of the total subjects showed a reduction in serum TG level. The subjects were classified into normal (TC