Short Synthesis of Polyoxygenated Macrocyclic Rings Using Acetal Linkages. Application to the Preparation of a New Lipidic Polyamine

A short preparation of polyoxygenated macrocycles can be carried out by combining the formation of an acetal linkage, to introduce long alkyl chains, with a ring closure metathesis. As an example, this methodology was used to synthesize a new polyamino lipid.

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Bibliographic Details
Published in:Journal of organic chemistry 2004-10, Vol.69 (20), p.6949-6952
Main Authors: Miramon, Marie-Laure, Mignet, Nathalie, Herscovici, Jean
Format: Article
Language:English
Subjects:
Acetals - chemistry
Chemistry
Exact sciences and technology
Genetic Vectors - chemical synthesis
Lipids
Lipids - chemical synthesis
Macrocyclic Compounds - chemistry
Models, Chemical
Molecular Structure
Organic chemistry
Polyamines - chemical synthesis
Preparations and properties
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Description
Summary:A short preparation of polyoxygenated macrocycles can be carried out by combining the formation of an acetal linkage, to introduce long alkyl chains, with a ring closure metathesis. As an example, this methodology was used to synthesize a new polyamino lipid.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0493020