New diterpenoids from the marine mangrove Bruguiera gymnorrhiza

Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane diterpenoids. All structures and the relative stereochemistry of the new compounds were determined b...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-09, Vol.67 (9), p.1620-1623
Main Authors: Han, L, Huang, X, Sattler, I, Dahse, H.M, Fu, H, Lin, W, Grabley, S
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Brackish
Bruguiera gymnorrhiza
China
Circular Dichroism
Diterpenes, Kaurane - chemistry
Diterpenes, Kaurane - isolation & purification
Diterpenes, Kaurane - pharmacology
Drug Screening Assays, Antitumor
General pharmacology
Humans
Marine
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Rhizophoraceae - chemistry
Stereoisomerism
Tumor Cells, Cultured
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Summary:Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane diterpenoids. All structures and the relative stereochemistry of the new compounds were determined by NMR spectroscopic studies. The absolute stereochemistry of 4 was determined by CD data. Some of the compounds showed moderate cytotoxic properties.
ISSN:0163-3864
1520-6025
DOI:10.1021/np040062t