A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition

In this study, we synthesized Fe 3O 4 magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone–silica monomer complex (EstSi) was synthesized by the reaction 3-(triethoxysilyl)propyl isocyanate with estrone,...

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Bibliographic Details
Published in:Talanta (Oxford) 2009-04, Vol.78 (2), p.327-332
Main Authors: Wang, Xin, Wang, Lianyan, He, Xiwen, Zhang, Yukui, Chen, Langxing
Format: Article
Language:English
Subjects:
Analytical chemistry
Biochemical separation
Chemistry
Coated Materials, Biocompatible
Estrone
Estrone - analysis
Estrone - isolation & purification
Exact sciences and technology
Fe 3O 4 magnetic nanoparticles
Ferric Compounds
Magnetics
Methods
Molecular Imprinting
Molecularly imprinted polymer
Nanocomposites - chemistry
Nanoparticles - chemistry
Silicon Dioxide
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Summary:In this study, we synthesized Fe 3O 4 magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone–silica monomer complex (EstSi) was synthesized by the reaction 3-(triethoxysilyl)propyl isocyanate with estrone, where the template was linked to the silica coating on the iron oxide core via a thermally reversible bond. The removal of the template by a simple thermal reaction produced specific estrone recognition sites on the surface of silica shell.The resulting estrone-imprinted polymer coating Fe 3O 4 magnetic hybrid nanoparticles exhibit a much higher specific recognition and saturation magnetization. The hybrid nanoparticles have been used for biochemical separation of estrone.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2008.11.024