Centromere Dynamics and Chromosome Evolution in Marsupials

The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meios...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of heredity 2004-09, Vol.95 (5), p.375-381
Main Authors: O'Neill, R. J., Eldridge, M. D. B., Metcalfe, C. J.
Format: Article
Language:English
Subjects:
Animals
Centromere - genetics
Chromosomes
Chromosomes, Mammalian - genetics
Eukaryotes
Evolution
Evolution, Molecular
Gene Rearrangement - genetics
Genetic Variation
Karyotyping
Marsupialia
Marsupialia - genetics
Marsupials
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3
cites cdi_FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3
container_end_page 381
container_issue 5
container_start_page 375
container_title The Journal of heredity
container_volume 95
creator O'Neill, R. J.
Eldridge, M. D. B.
Metcalfe, C. J.
description The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meiosis and mitosis notwithstanding, recent studies implicate the centromere as an active player in chromosome evolution and the divergence of species. This is exemplified by centromeric involvement in translocations, fusions, inversions, and centric shifts. Often species are defined karyotypically simply by the position of the centromere on certain chromosomes. Little is known about how the centromere, either as a functioning unit of chromatin or as a specific block of repetitive DNA sequences, acts in the creation of these types of chromosome rearrangements in an evolutionary context. Macropodine marsupials (kangaroos and wallabies) offer unique insights into current theories expositing centromere emergence during karyotypic diversification and speciation.
doi_str_mv 10.1093/jhered/esh063
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66909055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>713203481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3</originalsourceid><addsrcrecordid>eNqFkM1rGzEUxEVoiB0nx1zL0kNuWz_p6WOVW3CcuuC0lxRKL2K1lvC63l1H2g31f18VGwd6yWlg5sc83hByQ-EzBY3TzdoFt5q6uAaJZ2RMuRS5QsQPZAzAWE4F4IhcxrgBACo0XJARFVgUSooxuZu5tg9dk0qyh31bNnUVs7JdZbN1cruYkmz-2m2Hvu7arG6zpzLEYVeX23hFzn0Sd33UCfnxOH-eLfLl9y9fZ_fLvOKM97laCe89ciWVRWu1AMudp0pS5gpkwDhoi9yVzgum7YpWFdfcFxY9UkSLE3J76N2F7mVwsTdNHSu33Zat64ZopNSgQYh3QaqYUlDQBH76D9x0Q2jTE4bqgiEyqRKUH6AqdDEG580u1E0Z9oaC-Te9OUxvDtMn_uOxdLBNsk_0ceu3wjr27s8pL8Nvk84pYRY_f5lvWlKEYmkW-BdocY7R</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198233267</pqid></control><display><type>article</type><title>Centromere Dynamics and Chromosome Evolution in Marsupials</title><source>Oxford Journals Online</source><creator>O'Neill, R. J. ; Eldridge, M. D. B. ; Metcalfe, C. J.</creator><creatorcontrib>O'Neill, R. J. ; Eldridge, M. D. B. ; Metcalfe, C. J.</creatorcontrib><description>The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meiosis and mitosis notwithstanding, recent studies implicate the centromere as an active player in chromosome evolution and the divergence of species. This is exemplified by centromeric involvement in translocations, fusions, inversions, and centric shifts. Often species are defined karyotypically simply by the position of the centromere on certain chromosomes. Little is known about how the centromere, either as a functioning unit of chromatin or as a specific block of repetitive DNA sequences, acts in the creation of these types of chromosome rearrangements in an evolutionary context. Macropodine marsupials (kangaroos and wallabies) offer unique insights into current theories expositing centromere emergence during karyotypic diversification and speciation.</description><identifier>ISSN: 0022-1503</identifier><identifier>EISSN: 1465-7333</identifier><identifier>DOI: 10.1093/jhered/esh063</identifier><identifier>PMID: 15388765</identifier><identifier>CODEN: JOHEA8</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Centromere - genetics ; Chromosomes ; Chromosomes, Mammalian - genetics ; Eukaryotes ; Evolution ; Evolution, Molecular ; Gene Rearrangement - genetics ; Genetic Variation ; Karyotyping ; Marsupialia ; Marsupialia - genetics ; Marsupials</subject><ispartof>The Journal of heredity, 2004-09, Vol.95 (5), p.375-381</ispartof><rights>Copyright Oxford University Press(England) Sep/Oct 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3</citedby><cites>FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15388765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Neill, R. J.</creatorcontrib><creatorcontrib>Eldridge, M. D. B.</creatorcontrib><creatorcontrib>Metcalfe, C. J.</creatorcontrib><title>Centromere Dynamics and Chromosome Evolution in Marsupials</title><title>The Journal of heredity</title><addtitle>J Hered</addtitle><description>The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meiosis and mitosis notwithstanding, recent studies implicate the centromere as an active player in chromosome evolution and the divergence of species. This is exemplified by centromeric involvement in translocations, fusions, inversions, and centric shifts. Often species are defined karyotypically simply by the position of the centromere on certain chromosomes. Little is known about how the centromere, either as a functioning unit of chromatin or as a specific block of repetitive DNA sequences, acts in the creation of these types of chromosome rearrangements in an evolutionary context. Macropodine marsupials (kangaroos and wallabies) offer unique insights into current theories expositing centromere emergence during karyotypic diversification and speciation.</description><subject>Animals</subject><subject>Centromere - genetics</subject><subject>Chromosomes</subject><subject>Chromosomes, Mammalian - genetics</subject><subject>Eukaryotes</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Gene Rearrangement - genetics</subject><subject>Genetic Variation</subject><subject>Karyotyping</subject><subject>Marsupialia</subject><subject>Marsupialia - genetics</subject><subject>Marsupials</subject><issn>0022-1503</issn><issn>1465-7333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkM1rGzEUxEVoiB0nx1zL0kNuWz_p6WOVW3CcuuC0lxRKL2K1lvC63l1H2g31f18VGwd6yWlg5sc83hByQ-EzBY3TzdoFt5q6uAaJZ2RMuRS5QsQPZAzAWE4F4IhcxrgBACo0XJARFVgUSooxuZu5tg9dk0qyh31bNnUVs7JdZbN1cruYkmz-2m2Hvu7arG6zpzLEYVeX23hFzn0Sd33UCfnxOH-eLfLl9y9fZ_fLvOKM97laCe89ciWVRWu1AMudp0pS5gpkwDhoi9yVzgum7YpWFdfcFxY9UkSLE3J76N2F7mVwsTdNHSu33Zat64ZopNSgQYh3QaqYUlDQBH76D9x0Q2jTE4bqgiEyqRKUH6AqdDEG580u1E0Z9oaC-Te9OUxvDtMn_uOxdLBNsk_0ceu3wjr27s8pL8Nvk84pYRY_f5lvWlKEYmkW-BdocY7R</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>O'Neill, R. J.</creator><creator>Eldridge, M. D. B.</creator><creator>Metcalfe, C. J.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Centromere Dynamics and Chromosome Evolution in Marsupials</title><author>O'Neill, R. J. ; Eldridge, M. D. B. ; Metcalfe, C. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Centromere - genetics</topic><topic>Chromosomes</topic><topic>Chromosomes, Mammalian - genetics</topic><topic>Eukaryotes</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Gene Rearrangement - genetics</topic><topic>Genetic Variation</topic><topic>Karyotyping</topic><topic>Marsupialia</topic><topic>Marsupialia - genetics</topic><topic>Marsupials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Neill, R. J.</creatorcontrib><creatorcontrib>Eldridge, M. D. B.</creatorcontrib><creatorcontrib>Metcalfe, C. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Neill, R. J.</au><au>Eldridge, M. D. B.</au><au>Metcalfe, C. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Centromere Dynamics and Chromosome Evolution in Marsupials</atitle><jtitle>The Journal of heredity</jtitle><addtitle>J Hered</addtitle><date>2004-09</date><risdate>2004</risdate><volume>95</volume><issue>5</issue><spage>375</spage><epage>381</epage><pages>375-381</pages><issn>0022-1503</issn><eissn>1465-7333</eissn><coden>JOHEA8</coden><abstract>The eukaryotic centromere poses an interesting evolutionary paradox: it is a chromatin entity indispensable to precise chromosome segregation in all eukaryotes, yet the DNA at the heart of the centromere is remarkably variable. Its important role of spindle attachment to the kinetochore during meiosis and mitosis notwithstanding, recent studies implicate the centromere as an active player in chromosome evolution and the divergence of species. This is exemplified by centromeric involvement in translocations, fusions, inversions, and centric shifts. Often species are defined karyotypically simply by the position of the centromere on certain chromosomes. Little is known about how the centromere, either as a functioning unit of chromatin or as a specific block of repetitive DNA sequences, acts in the creation of these types of chromosome rearrangements in an evolutionary context. Macropodine marsupials (kangaroos and wallabies) offer unique insights into current theories expositing centromere emergence during karyotypic diversification and speciation.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>15388765</pmid><doi>10.1093/jhered/esh063</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0022-1503
ispartof The Journal of heredity, 2004-09, Vol.95 (5), p.375-381
issn 0022-1503
1465-7333
language eng
recordid cdi_proquest_miscellaneous_66909055
source Oxford Journals Online
subjects Animals
Centromere - genetics
Chromosomes
Chromosomes, Mammalian - genetics
Eukaryotes
Evolution
Evolution, Molecular
Gene Rearrangement - genetics
Genetic Variation
Karyotyping
Marsupialia
Marsupialia - genetics
Marsupials
title Centromere Dynamics and Chromosome Evolution in Marsupials
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A00%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Centromere%20Dynamics%20and%20Chromosome%20Evolution%20in%20Marsupials&rft.jtitle=The%20Journal%20of%20heredity&rft.au=O'Neill,%20R.%20J.&rft.date=2004-09&rft.volume=95&rft.issue=5&rft.spage=375&rft.epage=381&rft.pages=375-381&rft.issn=0022-1503&rft.eissn=1465-7333&rft.coden=JOHEA8&rft_id=info:doi/10.1093/jhered/esh063&rft_dat=%3Cproquest_cross%3E713203481%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c424t-7d5fff34767b3bb950b4ef17612e83202409b34eaef529bd1cc494f8b3f3133b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=198233267&rft_id=info:pmid/15388765&rfr_iscdi=true