VEGF and MVD expression in sinus augmentation with autologous bone and several graft materials

• Published in: Oral diseases 2009-03, Vol.15 (2), p.148-154
• Main Authors: Boëck-Neto, RJ, Artese, L, Piattelli, A, Shibli, JA, Perrotti, V, Piccirilli, M, Marcantonio Jr, E
• Format: Article
• Language: English
• Subjects: Alveolar Process - blood supply; Alveolar Process - physiology; Alveolar Process - surgery; Alveolar Ridge Augmentation - methods; Biocompatible Materials - therapeutic use; Bone Regeneration - drug effects; Bone Substitutes - therapeutic use; Bone Transplantation - methods; Calcium Phosphates - therapeutic use; Dentistry; graft materials/guided bone regeneration; Humans; Hydroxyapatites - therapeutic use; Maxilla - blood supply; Maxilla - physiology; Maxilla - surgery; Maxillary Sinus - blood supply; Maxillary Sinus - physiology; Maxillary Sinus - surgery; maxillary sinus augmentation; microvessel density; Microvessels - drug effects; Microvessels - growth & development; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - physiology; Osseointegration - physiology; Resins, Plant - therapeutic use; Ricinus; Ricinus communis; vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/j.1601-0825.2008.01502.x

Objective:  The aim of this study was to assess vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in maxillary sinus augmentation with autogenous bone and different graft materials for evaluating their angiogenic potential. Methods:  Biopsies were harvested 10 months after sinus augmentation with a combination of autogenous bone and different graft materials: hydroxyapatite (HA, n = 6 patients), demineralized freeze‐dried bone allograft (DFDBA, n = 5 patients), calcium phosphate (CP, n = 5 patients), Ricinus communis polymer (n = 5 patients) and control group – autogenous bone only (n = 13 patients). Results:  In all the samples, higher intensities of VEGF expression were prevalent in the newly formed bone, while lower intensities of VEGF expression were predominant in the areas of mature bone. The highest intensity of VEGF expression in the newly formed bone was expressed by HA (P