Association of Interleukin 23 Receptor Variants with Psoriatic Arthritis

Objective. A recent genome-wide pooling study noted a significant association of interleukin 23 receptor (IL-23R) and psoriasis. Overxpression of IL-23 has been detected in lesional psoriatic skin, and induces epidermal proliferation. Given the interplay between psoriasis and PsA, we examined the as...

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Bibliographic Details
Published in:Journal of rheumatology 2009-01, Vol.36 (1), p.137-140
Main Authors: RAHMAN, Proton, INMAN, Robert D, MAKSYMOWYCH, Walter P, REEVE, Jeff P, PEDDLE, Lynette, GLADMAN, Dafna D
Format: Article
Language:English
Subjects:
Adult
Arthritis, Psoriatic - genetics
Biological and medical sciences
Canada
Cohort Studies
Crohn Disease - genetics
Dermatology
Diseases of the osteoarticular system
Diseases of the spine
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Haplotypes
Humans
Inflammatory joint diseases
Interleukin-23 - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Psoriasis. Parapsoriasis. Lichen
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Summary:Objective. A recent genome-wide pooling study noted a significant association of interleukin 23 receptor (IL-23R) and psoriasis. Overxpression of IL-23 has been detected in lesional psoriatic skin, and induces epidermal proliferation. Given the interplay between psoriasis and PsA, we examined the association of IL-23R variants in 2 independent Canadian Caucasian cohorts of patients with psoriatic arthritis (PsA). Methods. We examined 496 PsA probands and 476 controls. Cases and controls were genotyped for a panel of 11 single-nucleotide polymorphisms (SNP) in IL-23R. Allele and haplotype associations were calculated using WHAP software. P values for haplotype associations were calculated using a permutation test. Results. The 381Gln allele of the coding SNP Arg381Gln (rs11209026) was found to be protective in the Canadian population (p = 0.004; corrected p = 0.044).A 2-marker haplotype from SNP rs7530511 and rs11209026 was associated with PsA (p = 0.011). All 3-marker sliding windows containing SNP rs11209026 were associated with PsA (p = 0.02 for all 3 windows). The magnitude of effect of IL-23R association in PsA appears to be similar to that reported in uncomplicated psoriasis. Conclusion. Significant associations between Arg381Gln SNP and haplotypes encoding this variant were noted in PsA. It remains to be determined what contribution of this association, if any, is specifically due to the inflammatory arthritis (PsA) rather than psoriasis. Key Indexing Terms: PSORIATIC ARTHRITIS PSORIASIS INTERLEUKIN 23R GENETIC ASSOCIATION Arg381Gln SINGLE-NUCLEOTIDE POLYMORPHISM
ISSN:0315-162X
1499-2752
DOI:10.3899/jrheum.080458