Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification

Background: A relation between low folate status and depression has been recognized since the 1960s. Since 1998, flour in the United States has been fortified with folic acid, and the prevalence of folate deficiency has decreased dramatically. Objective: We investigated whether, in this era of folic...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2004-10, Vol.80 (4), p.1024-1028
Main Authors: Ramos, M.I, Allen, L.H, Haan, M.N, Green, R, Miller, J.W
Format: Article
Language:English
Subjects:
Acculturation
Aged
Aging - blood
Biological and medical sciences
blood chemistry
California - epidemiology
Cross-Sectional Studies
depression
Depression - blood
Depression - diagnosis
Depression - ethnology
Depression - etiology
depressive symptoms
Diet
elderly
Feeding. Feeding behavior
Female
folic acid
Folic Acid - administration & dosage
Folic Acid - blood
Folic Acid Deficiency - blood
Folic Acid Deficiency - complications
Folic Acid Deficiency - epidemiology
Folic Acid Deficiency - ethnology
food intake
Food, Fortified
fortified foods
Fundamental and applied biological sciences. Psychology
Hispanic Americans
Hispanic or Latino
Hispanics
Homocysteine - blood
human diseases
Humans
Logistic Models
Male
Mental depression
Middle Aged
Older people
Plasma
Sex Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B
Vitamin B 12 - blood
vitamin content
vitamin deficiencies
Women
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Summary:Background: A relation between low folate status and depression has been recognized since the 1960s. Since 1998, flour in the United States has been fortified with folic acid, and the prevalence of folate deficiency has decreased dramatically. Objective: We investigated whether, in this era of folic acid fortification, low folate status is a determinant of depressive symptoms in a cohort of elderly Latinos (aged > or = 60 y) participating in the Sacramento Area Latino Study on Aging (SALSA). Design: In a cross-sectional logistic regression analysis of data from SALSA (n = 627 M, 883 F), odds ratios (ORs) were ascertained for elevated depressive symptoms [Center for Epidemiologic Studies Depression Scale (CES-D) score 16] among tertiles of plasma folate. Depressive symptoms were assessed by using the CES-D. Plasma folate concentrations were determined by radioassay. Results: The prevalence of folate deficiency (plasma folate < or = 6.8 nmol/L) in the SALSA population was
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/80.4.1024