A high prevalence of organ-specific autoimmunity in patients with bipolar disorder

In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). AT...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2004-10, Vol.56 (7), p.476-482
Main Authors: Padmos, Roos C., Bekris, Lynn, Knijff, Esther M., Tiemeier, Henning, Kupka, Ralph W., Cohen, Dan, Nolen, Willem A., Lernmark, Åke, Drexhage, Hemmo A.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Autoantibodies - blood
Autoantibodies - immunology
Autoantigens - immunology
Behavioral psychophysiology
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - immunology
Bipolar disorders
Cross-Sectional Studies
Female
Fundamental and applied biological sciences. Psychology
GAD65 autoantibodies
Gastritis, Atrophic - immunology
Glutamate Decarboxylase - immunology
H(+)-K(+)-Exchanging ATPase - immunology
H/K ATPase autoantibodies
Humans
Immunology and behavior
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Isoenzymes - immunology
Male
Medical sciences
Mood disorders
Organ Specificity - immunology
Pancrelipase - immunology
Parietal Cells, Gastric - immunology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Receptors, Interleukin-2 - blood
Reference Values
Schizophrenia - blood
Schizophrenia - immunology
sIL-2R
TPO-antibodies
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Summary:In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared with those in healthy control subjects (11.7 vs. 6.1% and 11.3 vs. 2.6% respectively; p
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2004.07.003