N-glycan production in the endoplasmic reticulum of plants

N-glycosylation is a complex process that encompasses the biosynthesis and modification of sugar moieties in the endoplasmic reticulum (ER) and Golgi. The ER-localized steps of N-glycan production in plants have received relatively little attention, despite their emerging roles in stress responses....

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Bibliographic Details
Published in:Trends in plant science 2009-02, Vol.14 (2), p.92-99
Main Authors: Pattison, Richard J., Amtmann, Anna
Format: Article
Language:English
Subjects:
Carbohydrate Metabolism
disease resistance
endoplasmic reticulum
Endoplasmic Reticulum - metabolism
glycolipids
glycoproteins
glycosylation
host-pathogen relationships
lipid metabolism
literature reviews
oligosaccharides
Plant Cells
plant response
plant stress
polysaccharides
Polysaccharides - biosynthesis
post-translational modification
protein folding
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Summary:N-glycosylation is a complex process that encompasses the biosynthesis and modification of sugar moieties in the endoplasmic reticulum (ER) and Golgi. The ER-localized steps of N-glycan production in plants have received relatively little attention, despite their emerging roles in stress responses. Here, we integrate information on the molecular components underlying the three stages of N-glycan production: lipid-linked oligosaccharide synthesis, co-translational oligosaccharyl-transfer and quality control of the folded glycoprotein in the ER. The relative importance of each step for N-glycosylation and plant performance is evaluated on the basis of studies with inhibitors and mutant phenotypes. Finally, we highlight the increasing evidence for crosstalk between N-glycan production and defence responses in plants and discuss the practical implications for pathogen resistance.
ISSN:1360-1385
1878-4372
DOI:10.1016/j.tplants.2008.11.008