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The Response of Malignant B Lymphocytes to Ionizing Radiation: Cell Cycle Arrest, Apoptosis and Protection against the Cytotoxic Effects of the Mitotic Inhibitor Nocodazole

Landsverk, K. S., Lyng, H. and Stokke, T. The Response of Malignant B Lymphocytes to Ionizing Radiation: Cell Cycle Arrest, Apoptosis and Protection against the Cytotoxic Effects of the Mitotic Inhibitor Nocodazole. Radiat. Res. 162, 405–415 (2004). Ionizing radiation and mitotic inhibitors are used...

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Published in:Radiation research 2004-10, Vol.162 (4), p.405-415
Main Authors: Landsverk, Kirsti Solberg, Lyng, Heidi, Stokke, Trond
Format: Article
Language:English
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Summary:Landsverk, K. S., Lyng, H. and Stokke, T. The Response of Malignant B Lymphocytes to Ionizing Radiation: Cell Cycle Arrest, Apoptosis and Protection against the Cytotoxic Effects of the Mitotic Inhibitor Nocodazole. Radiat. Res. 162, 405–415 (2004). Ionizing radiation and mitotic inhibitors are used for the treatment of lymphoma. We have studied cell cycle arrest and apoptosis of three human B-lymphocyte cell lines after X irradiation and/or nocodazole treatment. Radiation (4 and 6 Gy) caused arrest in the G2 phase of the cell cycle as well as in G1 in Reh cells with an intact TP53 response. Reh cells, but not U698 and Daudi cells with defects in the TP53 pathway, died by apoptosis after exposure to 4 or 6 Gy radiation (>15% apoptotic Reh cells and
ISSN:0033-7587
1938-5404
DOI:10.1667/RR3235