Cross-sectional evaluation of brachial artery flow-mediated vasodilation and C-reactive protein in healthy individuals

• Published in: European heart journal 2004-10, Vol.25 (19), p.1754-1760
• Main Authors: Verma, Subodh, Wang, Chao-Hung, Lonn, Eva, Charbonneau, Francois, Buithieu, Jean, Title, Lawrence M., Fung, Marinda, Edworthy, Steve, Robertson, Annette C., Anderson, Todd J.
• Format: Article
• Language: English
• Subjects: Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - physiology; Brachial Artery - physiology; C-Reactive Protein - metabolism; Cardiology. Vascular system; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Cross-Sectional Studies; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Risk Factors; Vasodilation - physiology
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1016/j.ehj.2004.06.039

Aims The present study was designed to (a) examine the interrelationship between endothelial function and CRP in healthy individuals and (b) evaluate the relationship of each biomarker towards global Framingham risk scores. Methods and results Brachial artery flow-mediated vasodilatation (FMD), CRP, and traditional cardiovascular risk factors were measured in the Firefighters and Their Endothelium (FATE) study, which recruited 1154 male participants (mean age 47.4±9.8 years) with no known history of cardiovascular disease. No relationship was observed between FMD and CRP (p=0.96). FMD and the Framingham risk score tended to correlate but not significantly (p=0.07). A lower FMD was related to a higher systolic and diastolic blood pressure (p