Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator

The sequence-length-dependent adsorption of single-stranded DNA (ssDNA) on unmodified gold nanoparticles is exploited as a new mechanism for colorimetric nuclease assay and measurement of oxidative DNA damage.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2009-01 (8), p.929-931
Main Authors: Shen, Qinpeng, Nie, Zhou, Guo, Manli, Zhong, Chuan-Jian, Lin, Bin, Li, Wang, Yao, Shouzhuo
Format: Article
Language:English
Subjects:
Adsorption
Colorimetry - methods
DNA Damage
DNA, Single-Stranded - chemistry
Gold - chemistry
Indicators and Reagents
Metal Nanoparticles - chemistry
Oxidation-Reduction
Time Factors
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Description
Summary:The sequence-length-dependent adsorption of single-stranded DNA (ssDNA) on unmodified gold nanoparticles is exploited as a new mechanism for colorimetric nuclease assay and measurement of oxidative DNA damage.
ISSN:1359-7345
1364-548X
DOI:10.1039/b818081d