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Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial
Aim: This multi‐centre, prospective, controlled trial was designed to examine the biological response of the matrix metalloproteinase(MMP) inhibitor subantimicrobial dose doxycycline (SDD) combined with access flap surgery on periodontal wound repair in patients with chronic severe periodontitis. Ma...
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| Published in: | Journal of clinical periodontology 2009-02, Vol.36 (2), p.149-156 |
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| cites | cdi_FETCH-LOGICAL-c4861-c04c64d7a829f74f9c84c01f4126a6976a53951369a29f8eabdd03038e4e46aa3 |
| container_end_page | 156 |
| container_issue | 2 |
| container_start_page | 149 |
| container_title | Journal of clinical periodontology |
| container_volume | 36 |
| creator | Gapski, Ricardo Hasturk, Hatice Van Dyke, Thomas E. Oringer, Richard J. Wang, Shufang Braun, Thomas M. Giannobile, William V. |
| description | Aim: This multi‐centre, prospective, controlled trial was designed to examine the biological response of the matrix metalloproteinase(MMP) inhibitor subantimicrobial dose doxycycline (SDD) combined with access flap surgery on periodontal wound repair in patients with chronic severe periodontitis.
Material and Methods: Seventy subjects were enrolled into a 12‐month, randomized, placebo‐controlled, double‐masked trial to evaluate disease response to 6 months therapy and “wash‐out” of either placebo+surgery or SDD (20 mg b.i.d.)+surgery. Primary outcome measure included clinical attachment levels (CAL) and secondary outcomes included probing depth (PD), bleeding on probing (BOP), as well as gingival crevicular fluid bone marker assessment [collagen telopeptides (ICTP)]. These measurements were taken at baseline through 12 months post‐surgery and drug administration.
Results: Patients treated with SDD and surgery demonstrated stronger reductions in PD in surgically‐treated sites of 7 mm as well as gains in CAL (p |
| doi_str_mv | 10.1111/j.1600-051X.2008.01351.x |
| format | article |
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Material and Methods: Seventy subjects were enrolled into a 12‐month, randomized, placebo‐controlled, double‐masked trial to evaluate disease response to 6 months therapy and “wash‐out” of either placebo+surgery or SDD (20 mg b.i.d.)+surgery. Primary outcome measure included clinical attachment levels (CAL) and secondary outcomes included probing depth (PD), bleeding on probing (BOP), as well as gingival crevicular fluid bone marker assessment [collagen telopeptides (ICTP)]. These measurements were taken at baseline through 12 months post‐surgery and drug administration.
Results: Patients treated with SDD and surgery demonstrated stronger reductions in PD in surgically‐treated sites of 7 mm as well as gains in CAL (p<0.004). Furthermore, SDD+surgery resulted in short‐term reductions in ICTP levels compared with placebo. Rebounds in ICTP levels and clinical parameters occurred when SDD was withdrawn.
Conclusions: The results from this multi‐centre study suggests that SDD in combination with surgery improves the short‐term response of periodontal therapy by reducing PD, increasing CAL gain and inhibiting early stage bone resorption.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/j.1600-051X.2008.01351.x</identifier><identifier>PMID: 19207891</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Chronic Periodontitis - drug therapy ; Chronic Periodontitis - enzymology ; Chronic Periodontitis - surgery ; Collagen Type I - analysis ; Dentistry ; Double-Blind Method ; doxycycline ; Doxycycline - analogs & derivatives ; Doxycycline - therapeutic use ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Gingival Crevicular Fluid - chemistry ; Humans ; Male ; matrix metalloproteinases ; Matrix Metalloproteinases - metabolism ; Medical sciences ; Middle Aged ; MMP ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Peptides - analysis ; periodontal ; Pharmacology. Drug treatments ; Prospective Studies ; Tissue Inhibitor of Metalloproteinases - therapeutic use ; wound healing</subject><ispartof>Journal of clinical periodontology, 2009-02, Vol.36 (2), p.149-156</ispartof><rights>2009 John Wiley & Sons A/S. Journal compilation © 2009 John Wiley & Sons A/S</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4861-c04c64d7a829f74f9c84c01f4126a6976a53951369a29f8eabdd03038e4e46aa3</citedby><cites>FETCH-LOGICAL-c4861-c04c64d7a829f74f9c84c01f4126a6976a53951369a29f8eabdd03038e4e46aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21062345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19207891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gapski, Ricardo</creatorcontrib><creatorcontrib>Hasturk, Hatice</creatorcontrib><creatorcontrib>Van Dyke, Thomas E.</creatorcontrib><creatorcontrib>Oringer, Richard J.</creatorcontrib><creatorcontrib>Wang, Shufang</creatorcontrib><creatorcontrib>Braun, Thomas M.</creatorcontrib><creatorcontrib>Giannobile, William V.</creatorcontrib><title>Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim: This multi‐centre, prospective, controlled trial was designed to examine the biological response of the matrix metalloproteinase(MMP) inhibitor subantimicrobial dose doxycycline (SDD) combined with access flap surgery on periodontal wound repair in patients with chronic severe periodontitis.
Material and Methods: Seventy subjects were enrolled into a 12‐month, randomized, placebo‐controlled, double‐masked trial to evaluate disease response to 6 months therapy and “wash‐out” of either placebo+surgery or SDD (20 mg b.i.d.)+surgery. Primary outcome measure included clinical attachment levels (CAL) and secondary outcomes included probing depth (PD), bleeding on probing (BOP), as well as gingival crevicular fluid bone marker assessment [collagen telopeptides (ICTP)]. These measurements were taken at baseline through 12 months post‐surgery and drug administration.
Results: Patients treated with SDD and surgery demonstrated stronger reductions in PD in surgically‐treated sites of 7 mm as well as gains in CAL (p<0.004). Furthermore, SDD+surgery resulted in short‐term reductions in ICTP levels compared with placebo. Rebounds in ICTP levels and clinical parameters occurred when SDD was withdrawn.
Conclusions: The results from this multi‐centre study suggests that SDD in combination with surgery improves the short‐term response of periodontal therapy by reducing PD, increasing CAL gain and inhibiting early stage bone resorption.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Chronic Periodontitis - drug therapy</subject><subject>Chronic Periodontitis - enzymology</subject><subject>Chronic Periodontitis - surgery</subject><subject>Collagen Type I - analysis</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>doxycycline</subject><subject>Doxycycline - analogs & derivatives</subject><subject>Doxycycline - therapeutic use</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Gingival Crevicular Fluid - chemistry</subject><subject>Humans</subject><subject>Male</subject><subject>matrix metalloproteinases</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MMP</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Peptides - analysis</subject><subject>periodontal</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Tissue Inhibitor of Metalloproteinases - therapeutic use</subject><subject>wound healing</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkV1v0zAUhi0EYmXwF5Bv4C7Bjj8Sc4GEqq0wdR9iQ3BnubYjXJy4sxOt3a-fs1blFt8cS37Oa5_HAECMSpzXp3WJOUIFYvh3WSHUlAgThsvtCzA7HrwEM0QQKbioxQl4k9IaIVwTQl6DEywqVDcCz8Bwu0uD7ZyGl5c30PV_3MoNLvSwDRFubHTBhH5QHj6EsTcw2o1y8XOuafRDgqGFCnZ56wpt-yFaGFVvQucerSl07ozBe2ug9q53OscM0Sn_FrxqlU_23aGegp_nZ3fzb8XyevF9_nVZaNpwXGhENaemVk0l2pq2QjdUI9xSXHGVx-KKEcEw4UJloLFqZcw0cmOppVwpcgo-7nM3MdyPNg2yc0lb71Vvw5gk5wIzxkQGmz2oY0gp2lZuoutU3EmM5GRcruUkVk5i5WRcPhuX29z6_nDHuOqs-dd4UJyBDwdApWygzYK0S0euwohXhLLMfdlzD87b3X8_QF7Mb86mbQ4o9gEu_-j2GKDiX8lrUjP562ohz-eLH0sqlpKTJzzIrT0</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Gapski, Ricardo</creator><creator>Hasturk, Hatice</creator><creator>Van Dyke, Thomas E.</creator><creator>Oringer, Richard J.</creator><creator>Wang, Shufang</creator><creator>Braun, Thomas M.</creator><creator>Giannobile, William V.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial</title><author>Gapski, Ricardo ; Hasturk, Hatice ; Van Dyke, Thomas E. ; Oringer, Richard J. ; Wang, Shufang ; Braun, Thomas M. ; Giannobile, William V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4861-c04c64d7a829f74f9c84c01f4126a6976a53951369a29f8eabdd03038e4e46aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Chronic Periodontitis - drug therapy</topic><topic>Chronic Periodontitis - enzymology</topic><topic>Chronic Periodontitis - surgery</topic><topic>Collagen Type I - analysis</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>doxycycline</topic><topic>Doxycycline - analogs & derivatives</topic><topic>Doxycycline - therapeutic use</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Gingival Crevicular Fluid - chemistry</topic><topic>Humans</topic><topic>Male</topic><topic>matrix metalloproteinases</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MMP</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Peptides - analysis</topic><topic>periodontal</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Tissue Inhibitor of Metalloproteinases - therapeutic use</topic><topic>wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gapski, Ricardo</creatorcontrib><creatorcontrib>Hasturk, Hatice</creatorcontrib><creatorcontrib>Van Dyke, Thomas E.</creatorcontrib><creatorcontrib>Oringer, Richard J.</creatorcontrib><creatorcontrib>Wang, Shufang</creatorcontrib><creatorcontrib>Braun, Thomas M.</creatorcontrib><creatorcontrib>Giannobile, William V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gapski, Ricardo</au><au>Hasturk, Hatice</au><au>Van Dyke, Thomas E.</au><au>Oringer, Richard J.</au><au>Wang, Shufang</au><au>Braun, Thomas M.</au><au>Giannobile, William V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2009-02</date><risdate>2009</risdate><volume>36</volume><issue>2</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim: This multi‐centre, prospective, controlled trial was designed to examine the biological response of the matrix metalloproteinase(MMP) inhibitor subantimicrobial dose doxycycline (SDD) combined with access flap surgery on periodontal wound repair in patients with chronic severe periodontitis.
Material and Methods: Seventy subjects were enrolled into a 12‐month, randomized, placebo‐controlled, double‐masked trial to evaluate disease response to 6 months therapy and “wash‐out” of either placebo+surgery or SDD (20 mg b.i.d.)+surgery. Primary outcome measure included clinical attachment levels (CAL) and secondary outcomes included probing depth (PD), bleeding on probing (BOP), as well as gingival crevicular fluid bone marker assessment [collagen telopeptides (ICTP)]. These measurements were taken at baseline through 12 months post‐surgery and drug administration.
Results: Patients treated with SDD and surgery demonstrated stronger reductions in PD in surgically‐treated sites of 7 mm as well as gains in CAL (p<0.004). Furthermore, SDD+surgery resulted in short‐term reductions in ICTP levels compared with placebo. Rebounds in ICTP levels and clinical parameters occurred when SDD was withdrawn.
Conclusions: The results from this multi‐centre study suggests that SDD in combination with surgery improves the short‐term response of periodontal therapy by reducing PD, increasing CAL gain and inhibiting early stage bone resorption.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19207891</pmid><doi>10.1111/j.1600-051X.2008.01351.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical periodontology, 2009-02, Vol.36 (2), p.149-156 |
| issn | 0303-6979 1600-051X |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chronic Periodontitis - drug therapy Chronic Periodontitis - enzymology Chronic Periodontitis - surgery Collagen Type I - analysis Dentistry Double-Blind Method doxycycline Doxycycline - analogs & derivatives Doxycycline - therapeutic use Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Gingival Crevicular Fluid - chemistry Humans Male matrix metalloproteinases Matrix Metalloproteinases - metabolism Medical sciences Middle Aged MMP Non tumoral diseases Otorhinolaryngology. Stomatology Peptides - analysis periodontal Pharmacology. Drug treatments Prospective Studies Tissue Inhibitor of Metalloproteinases - therapeutic use wound healing |
| title | Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial |
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