Modification of biological activity of lipopolysaccharide in the complex with chitosan

In the complex with chitosan, lipopolysaccharide partially lost its ability to induce lymphokines tumor necrosis factor and interleukin-8, but retained immunostimulating properties and increased phagocytic function of macrophages by improving digestion of bacteria.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-04, Vol.137 (4), p.379-381
Main Authors: Ermak, I M, Davydova, V N, Gorbach, V I, Berdyshev, E L, Kuznetsova, T A, Ivanushko, I A, Gazha, A K, Smolina, T P, Zaporozhets, T S, Solov'eva, T F
Format: Article
Language:English
Subjects:
Animals
Chitosan - immunology
Escherichia coli - metabolism
Interleukin-8 - immunology
Lipopolysaccharides - immunology
Macromolecular Substances
Macrophages, Peritoneal - immunology
Mice
Spleen - cytology
Spleen - immunology
Tumor Necrosis Factor-alpha - immunology
Yersinia pseudotuberculosis - metabolism
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Description
Summary:In the complex with chitosan, lipopolysaccharide partially lost its ability to induce lymphokines tumor necrosis factor and interleukin-8, but retained immunostimulating properties and increased phagocytic function of macrophages by improving digestion of bacteria.
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000035136.61014.c2