Vitamin E Protects DNA from Oxidative Damage in Human Hepatocellular Carcinoma Cell Lines

Expression of multiple drug resistant (MDR) phenotype and over-expression of P-glycoprotein (P-gp) in the human hepatocellular carcinoma (HCC) cell clone P1(0.5), derived from the PLC/PRF/5 cell line (P5), are associated with strong resistance to oxidative stress and a significant ( p

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Bibliographic Details
Published in:Free radical research 2004-07, Vol.38 (7), p.751-759
Main Authors: Fantappiè, Ornella, Lodovici, Maura, Fabrizio, Paola, Marchetti, Serena, Fabbroni, Valentina, Solazzo, Michela, Lasagna, Nadia, Pantaleo, Pietro, Mazzanti, Roberto
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - analogs & derivatives
Adenosine Diphosphate - pharmacology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - biosynthesis
DNA damage
DNA Damage - drug effects
DNA Damage - radiation effects
Humans
Liver cancer
Multiple drug resistance
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Oxidative Stress - radiation effects
Radiation, Ionizing
Radio-protection
Thiobarbituric Acid Reactive Substances - metabolism
Tocopherols
Tumor Stem Cell Assay
Vitamin E
Vitamin E - analogs & derivatives
Vitamin E - metabolism
Vitamin E - pharmacology
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Summary:Expression of multiple drug resistant (MDR) phenotype and over-expression of P-glycoprotein (P-gp) in the human hepatocellular carcinoma (HCC) cell clone P1(0.5), derived from the PLC/PRF/5 cell line (P5), are associated with strong resistance to oxidative stress and a significant ( p
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760410001705140