Selective Binding of Sucralfate to Endoscopic Mucosal Resection-Induced Gastric Ulcer: Evaluation of Aluminium Adherence

We evaluated the effect of sucralfate in patients with early gastric cancer in endoscopic mucosal resection (EMR)-induced gastric ulcers, and in rats with acetic acid-induced ulcers, by measuring concentrations of aluminium adhering to mucosal lesions. Twenty-two patients who underwent EMR received...

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Bibliographic Details
Published in:Journal of international medical research 2004-09, Vol.32 (5), p.520-529
Main Authors: Itoh, T, Kusaka, K, Kawaura, K, Kashimura, K, Yamakawa, J, Takahashi, T, Kanda, T
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aluminum - metabolism
Animals
Anti-Ulcer Agents - metabolism
Anti-Ulcer Agents - therapeutic use
Disease Models, Animal
Female
Gastric Juice - chemistry
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gastroscopy
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Ranitidine - therapeutic use
Rats
Rats, Sprague-Dawley
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach Ulcer - drug therapy
Stomach Ulcer - metabolism
Stomach Ulcer - pathology
Sucralfate - metabolism
Sucralfate - therapeutic use
Wound Healing
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Summary:We evaluated the effect of sucralfate in patients with early gastric cancer in endoscopic mucosal resection (EMR)-induced gastric ulcers, and in rats with acetic acid-induced ulcers, by measuring concentrations of aluminium adhering to mucosal lesions. Twenty-two patients who underwent EMR received sucralfate with or without ranitidine and were examined endoscopically after 1 week, 2 weeks and 3 weeks. Gastric juice pH and concentration of aluminium in samples of ulcerated and normal mucosa were measured at various time-points. Good ulcer healing was observed in all patients. Significantly higher concentrations of aluminium were found in ulcerated tissue compared with normal mucosa. This selective binding of sucralfate was even found 12 h after drug administration and was confirmed in acetic acid-induced ulcers in 40 rats. Neutral rather than acid gastric juice was observed up to 12 h after the administration of sucralfate alone. These results suggest that sucralfate with or without ranitidine may contribute to the healing of EMR-induced ulcers by selectively binding to lesions.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000403200510