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Selective Binding of Sucralfate to Endoscopic Mucosal Resection-Induced Gastric Ulcer: Evaluation of Aluminium Adherence
We evaluated the effect of sucralfate in patients with early gastric cancer in endoscopic mucosal resection (EMR)-induced gastric ulcers, and in rats with acetic acid-induced ulcers, by measuring concentrations of aluminium adhering to mucosal lesions. Twenty-two patients who underwent EMR received...
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| Published in: | Journal of international medical research 2004-09, Vol.32 (5), p.520-529 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c383t-9a9150838be662d27258d33ccce34800b6918630d0e44ad641a5606d02a0d8a03 |
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| cites | cdi_FETCH-LOGICAL-c383t-9a9150838be662d27258d33ccce34800b6918630d0e44ad641a5606d02a0d8a03 |
| container_end_page | 529 |
| container_issue | 5 |
| container_start_page | 520 |
| container_title | Journal of international medical research |
| container_volume | 32 |
| creator | Itoh, T Kusaka, K Kawaura, K Kashimura, K Yamakawa, J Takahashi, T Kanda, T |
| description | We evaluated the effect of sucralfate in patients with early gastric cancer in endoscopic mucosal resection (EMR)-induced gastric ulcers, and in rats with acetic acid-induced ulcers, by measuring concentrations of aluminium adhering to mucosal lesions. Twenty-two patients who underwent EMR received sucralfate with or without ranitidine and were examined endoscopically after 1 week, 2 weeks and 3 weeks. Gastric juice pH and concentration of aluminium in samples of ulcerated and normal mucosa were measured at various time-points. Good ulcer healing was observed in all patients. Significantly higher concentrations of aluminium were found in ulcerated tissue compared with normal mucosa. This selective binding of sucralfate was even found 12 h after drug administration and was confirmed in acetic acid-induced ulcers in 40 rats. Neutral rather than acid gastric juice was observed up to 12 h after the administration of sucralfate alone. These results suggest that sucralfate with or without ranitidine may contribute to the healing of EMR-induced ulcers by selectively binding to lesions. |
| doi_str_mv | 10.1177/147323000403200510 |
| format | article |
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Twenty-two patients who underwent EMR received sucralfate with or without ranitidine and were examined endoscopically after 1 week, 2 weeks and 3 weeks. Gastric juice pH and concentration of aluminium in samples of ulcerated and normal mucosa were measured at various time-points. Good ulcer healing was observed in all patients. Significantly higher concentrations of aluminium were found in ulcerated tissue compared with normal mucosa. This selective binding of sucralfate was even found 12 h after drug administration and was confirmed in acetic acid-induced ulcers in 40 rats. Neutral rather than acid gastric juice was observed up to 12 h after the administration of sucralfate alone. These results suggest that sucralfate with or without ranitidine may contribute to the healing of EMR-induced ulcers by selectively binding to lesions.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/147323000403200510</identifier><identifier>PMID: 15458285</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Aged, 80 and over ; Aluminum - metabolism ; Animals ; Anti-Ulcer Agents - metabolism ; Anti-Ulcer Agents - therapeutic use ; Disease Models, Animal ; Female ; Gastric Juice - chemistry ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Gastroscopy ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Ranitidine - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Stomach Ulcer - drug therapy ; Stomach Ulcer - metabolism ; Stomach Ulcer - pathology ; Sucralfate - metabolism ; Sucralfate - therapeutic use ; Wound Healing</subject><ispartof>Journal of international medical research, 2004-09, Vol.32 (5), p.520-529</ispartof><rights>2004 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-9a9150838be662d27258d33ccce34800b6918630d0e44ad641a5606d02a0d8a03</citedby><cites>FETCH-LOGICAL-c383t-9a9150838be662d27258d33ccce34800b6918630d0e44ad641a5606d02a0d8a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/147323000403200510$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/147323000403200510$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/147323000403200510?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15458285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itoh, T</creatorcontrib><creatorcontrib>Kusaka, K</creatorcontrib><creatorcontrib>Kawaura, K</creatorcontrib><creatorcontrib>Kashimura, K</creatorcontrib><creatorcontrib>Yamakawa, J</creatorcontrib><creatorcontrib>Takahashi, T</creatorcontrib><creatorcontrib>Kanda, T</creatorcontrib><title>Selective Binding of Sucralfate to Endoscopic Mucosal Resection-Induced Gastric Ulcer: Evaluation of Aluminium Adherence</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>We evaluated the effect of sucralfate in patients with early gastric cancer in endoscopic mucosal resection (EMR)-induced gastric ulcers, and in rats with acetic acid-induced ulcers, by measuring concentrations of aluminium adhering to mucosal lesions. Twenty-two patients who underwent EMR received sucralfate with or without ranitidine and were examined endoscopically after 1 week, 2 weeks and 3 weeks. Gastric juice pH and concentration of aluminium in samples of ulcerated and normal mucosa were measured at various time-points. Good ulcer healing was observed in all patients. Significantly higher concentrations of aluminium were found in ulcerated tissue compared with normal mucosa. This selective binding of sucralfate was even found 12 h after drug administration and was confirmed in acetic acid-induced ulcers in 40 rats. Neutral rather than acid gastric juice was observed up to 12 h after the administration of sucralfate alone. These results suggest that sucralfate with or without ranitidine may contribute to the healing of EMR-induced ulcers by selectively binding to lesions.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aluminum - metabolism</subject><subject>Animals</subject><subject>Anti-Ulcer Agents - metabolism</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Gastric Juice - chemistry</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastroscopy</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ranitidine - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - metabolism</subject><subject>Stomach Ulcer - pathology</subject><subject>Sucralfate - metabolism</subject><subject>Sucralfate - therapeutic use</subject><subject>Wound Healing</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kEtrGzEUhUVpady0fyCLoFV3k1w9LWfnBCcNJBTyWA-ydJ1M0EiONArpv-8MNnRRyOrC4Tsf3EPIEYMTxubzUybnggsAkCA4gGLwicymsJnSz2QG42lAgzog30p5GUGuFf9KDpiSynCjZuT9HgO6oXtDet5F38Unmjb0vrpsw8YOSIdEV9Gn4tK2c_S2ulRsoHdYplaKzXX01aGnV7YMeSQeg8N8RldvNlQ7EZNvGWrfxa72dOmfMWN0-J182dhQ8Mf-HpLHy9XDxa_m5vfV9cXypnHCiKFZ2AVTYIRZo9bc8zlXxgvhnEMhDcBaL5jRAjyglNZryazSoD1wC95YEIfk5867zem1YhnavisOQ7ARUy2t1gsutZxAvgNdTqVk3LTb3PU2_2kZtNPe7f97j6Xjvb2ue_T_KvuBR-B0BxT7hO1LqjmO336k_AsxdYfH</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Itoh, T</creator><creator>Kusaka, K</creator><creator>Kawaura, K</creator><creator>Kashimura, K</creator><creator>Yamakawa, J</creator><creator>Takahashi, T</creator><creator>Kanda, T</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Selective Binding of Sucralfate to Endoscopic Mucosal Resection-Induced Gastric Ulcer: Evaluation of Aluminium Adherence</title><author>Itoh, T ; 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| subjects | Aged Aged, 80 and over Aluminum - metabolism Animals Anti-Ulcer Agents - metabolism Anti-Ulcer Agents - therapeutic use Disease Models, Animal Female Gastric Juice - chemistry Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastroscopy Humans Hydrogen-Ion Concentration Male Middle Aged Ranitidine - therapeutic use Rats Rats, Sprague-Dawley Stomach Neoplasms - pathology Stomach Neoplasms - surgery Stomach Ulcer - drug therapy Stomach Ulcer - metabolism Stomach Ulcer - pathology Sucralfate - metabolism Sucralfate - therapeutic use Wound Healing |
| title | Selective Binding of Sucralfate to Endoscopic Mucosal Resection-Induced Gastric Ulcer: Evaluation of Aluminium Adherence |
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