Karyopherins: from nuclear-transport mediators to nuclear-function regulators

The karyopherin β (or importin β) family comprises soluble transport factors that mediate the movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have extended the role of karyopherins to regulating assembly of the nuclear pore complex (NPC), assembly of the nuclear envel...

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Bibliographic Details
Published in:Trends in cell biology 2004-10, Vol.14 (10), p.547-556
Main Authors: Mosammaparast, Nima, Pemberton, Lucy F.
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus - physiology
Animals
Cell Nucleus - chemistry
Cell Nucleus - physiology
Humans
Karyopherins - chemistry
Karyopherins - physiology
Nuclear Pore - chemistry
Nuclear Pore - physiology
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Summary:The karyopherin β (or importin β) family comprises soluble transport factors that mediate the movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have extended the role of karyopherins to regulating assembly of the nuclear pore complex (NPC), assembly of the nuclear envelope, mitosis and replication. New data also address how karyopherins specifically recognize and transport many distinct cargoes and traverse the NPC. These data raise the possibility that, although there might be a universal mechanism for nuclear transport, specific interactions between karyopherins and components of the NPC might function to regulate differentially the ability of the different karyopherins to cross the NPC.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2004.09.004