Cell cycle control: a complex issue

Do p27Kip1 and p21Cip1 function as activators or inhibitors of D cyclin-cdk4 activity? Attempts to answer this question, and thus to understand how cdk4--a key cell cycle regulator--becomes active, have produced conflicting data. In this perspective, we summarize the results of studies addressing th...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2004-03, Vol.3 (3), p.263-264
Main Authors: Olashaw, Nancy, Bagui, Tapan K, Pledger, W J
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - physiology
Cell Cycle Proteins - metabolism
Cyclin D
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases - metabolism
Cyclins - metabolism
Fibroblasts
Mice
Protein Binding
Proto-Oncogene Proteins - metabolism
Tumor Suppressor Proteins
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Summary:Do p27Kip1 and p21Cip1 function as activators or inhibitors of D cyclin-cdk4 activity? Attempts to answer this question, and thus to understand how cdk4--a key cell cycle regulator--becomes active, have produced conflicting data. In this perspective, we summarize the results of studies addressing the effects of p27Kip1 and p21Cip1 on the assembly and activation of D cyclin-cdk4 complexes. Emphasis is placed on our experimental findings that support a model of cell cycle control in which p27Kip1 and p21Cip1 stabilize D cyclin-cdk4 complexes but inhibit D cyclin-cdk4 activity.
ISSN:1538-4101