Azaphilone pigments from a yellow mutant of the fungus Monascus kaoliang

Azaphilone pigments, monascusones A ( 1) and B ( 2), were isolated from the extract of the fungus Monascus kaoliang grown on rice. Azaphilone pigments, monascusones A ( 1) and B ( 2), together with two known azaphilones, monascin ( 3) and FK17-P2b2 ( 4), were isolated from the CH 2Cl 2 extract of a...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2004-09, Vol.65 (18), p.2569-2575
Main Authors: Jongrungruangchok, Suchada, Kittakoop, Prasat, Yongsmith, Busaba, Bavovada, Rapepol, Tanasupawat, Somboon, Lartpornmatulee, Nattapat, Thebtaranonth, Yodhathai
Format: Article
Language:English
Subjects:
antibacterial properties
anticarcinogenic activity
antifungal properties
azaphilone
Azaphilone pigments
Benzopyrans - chemistry
Benzopyrans - isolation & purification
Benzopyrans - pharmacology
Candida albicans
Cell Line, Tumor
cell lines
chemical structure
Color
cytotoxicity
Eurotiales
Food colorant
food coloring
host plants
human health
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
monascin
Monascus - chemistry
Monascus - genetics
Monascus kaoliang
monascusone
Monascusone A
Monascusone B
mutants
Mutation - genetics
Mycobacterium tuberculosis
Oryza sativa
pigments
Pigments, Biological - chemistry
Pigments, Biological - isolation & purification
Pigments, Biological - pharmacology
Plasmodium falciparum
rice
secondary metabolites
spectral analysis
yeasts
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Summary:Azaphilone pigments, monascusones A ( 1) and B ( 2), were isolated from the extract of the fungus Monascus kaoliang grown on rice. Azaphilone pigments, monascusones A ( 1) and B ( 2), together with two known azaphilones, monascin ( 3) and FK17-P2b2 ( 4), were isolated from the CH 2Cl 2 extract of a yellow mutant of the fungus M. kaoliang grown on rice. Structures of the isolated compounds were elucidated by analyses of spectroscopic data. Monascusone A ( 1), the major metabolite of M. kaoliang, showed no antimalarial (against Plasmodium falciparum), antitubercular (against Mycobacterium tuberculosis H37Ra), and antifungal (toward Candida albicans) activities. Compound 1 exhibited no cytotoxicity against BC (breast cancer) and KB (human epidermoid carcinoma of cavity) cell lines.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2004.08.032