Demographic data, natural history, and prognostic factors of idiopathic thrombocytopenic purpura in children: A multicentered study from Argentina

Background Demographics, outcome, and management of idiopathic thrombocytopenic purpura (ITP) in children present differences between countries. Although several factors influence outcome, it is impossible to predict at diagnosis which patients will have acute or chronic disease. High rates of spont...

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Published in:Pediatric blood & cancer 2009-04, Vol.52 (4), p.491-496
Main Authors: Donato, Hugo, Picón, Armando, Martinez, Mónica, Rapetti, María Cristina, Rosso, Amadeo, Gomez, Sergio, Rossi, Nestor, Bacciedoni, Viviana, Schvartzman, Gabriel, Riccheri, Cecilia, Costa, Alejandra, Di Santo, Juan
Format: Article
Language:English
Subjects:
Adolescent
Age Distribution
Argentina - epidemiology
Child
Child, Preschool
Demography
Female
Humans
idiopathic thrombocytopenic purpura
immune thrombocytopenic purpura
Incidence
Infant
Male
platelets
Prognosis
purpura
Purpura, Thrombocytopenic, Idiopathic - epidemiology
Purpura, Thrombocytopenic, Idiopathic - physiopathology
Sex Distribution
splenectomy
thrombocytopenia
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Summary:Background Demographics, outcome, and management of idiopathic thrombocytopenic purpura (ITP) in children present differences between countries. Although several factors influence outcome, it is impossible to predict at diagnosis which patients will have acute or chronic disease. High rates of spontaneous remission in chronic ITP have been reported. Procedure Data concerning 1,683 patients with ITP diagnosed from 1981 to date are presented; outcome was evaluated in 1,418 children. Results Remarkable presenting features were an incidence peak in the first 2 years of age and male predominance in patients
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.21872