Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background

We have previously reported that Melanocortin 2 receptor (MC2R−/−) deficient mice on B6 N5 generations exhibited macroscopically detectable adrenal glands with markedly atrophied zona fasciculata (zF) and lack of detectable levels of corticosterone, and reduced serum concentrations of aldosterone an...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2009-03, Vol.300 (1-2), p.32-36
Main Authors: Chida, Dai, Sato, Tsuyoshi, Sato, Yoshinori, Kubo, Mitsumasa, Yoda, Tetsuya, Suzuki, Harumi, Iwakura, Yoichiro
Format: Article
Language:English
Subjects:
Animals
Corticosterone - blood
Familial glucocorticoid deficiency (FGD)
Female
Fertility
Glucocorticoid (GC)
Hypothalamic–pituitary–adrenal (HPA) axis
Interleukin-6 - blood
Kidney Glomerulus - cytology
Kidney Glomerulus - metabolism
Kidney Glomerulus - pathology
Lipopolysaccharides - metabolism
Lung - pathology
Lung - physiopathology
Male
Melanocortin 2 receptor (MC2R)
Mice
Mice, Inbred BALB C
Mice, Knockout
Proopiomelanocortin (POMC)
Receptor, Melanocortin, Type 2 - genetics
Receptor, Melanocortin, Type 2 - metabolism
Renin - genetics
Renin - metabolism
Renin–angiotensin–aldosterone system (RAAS)
Restraint, Physical
Stress, Psychological
Survival Rate
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Summary:We have previously reported that Melanocortin 2 receptor (MC2R−/−) deficient mice on B6 N5 generations exhibited macroscopically detectable adrenal glands with markedly atrophied zona fasciculata (zF) and lack of detectable levels of corticosterone, and reduced serum concentrations of aldosterone and epinephrine. All MC2R−/− mice on B6/N8 background die within 2 days after birth, while about half of the MC2R−/− mice on B6/Balbc mix background survived to adulthood. Both male and female MC2R−/− mice were fertile, suggesting that normal development and function of reproductive organs. MC2R−/− mice delivered from MC2R−/− dams failed to survive due to lung failure, suggesting that fetal or maternal corticosterone is essential for lung maturation. MC2R−/− mice failed to activate the hypothalamic–pituitary–adrenal axis in response to both immune and non-immune stimuli. MC2R−/− mice maintained glomerular structure and achieved electrolyte homeostasis by the activation of the renin–angiotensin–aldosterone system under low aldosterone and undetectable levels of corticosterone.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2008.10.027