Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study

Purpose Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. Methods PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patien...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2009-03, Vol.36 (3), p.347-353
Main Authors: Scott, Andrew M., Gunawardana, Dishan H., Wong, Joseph, Kirkwood, Ian, Hicks, Rodney J., Ho Shon, Ivan, Ramshaw, Jayne E., Robins, Peter
Format: Article
Language:English
Subjects:
Cardiology
Comparative studies
Disease-Free Survival
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Gallium Radioisotopes
Humans
Imaging
Lymphoma
Lymphoma, Non-Hodgkin - diagnostic imaging
Lymphoma, Non-Hodgkin - pathology
Medical imaging
Medical prognosis
Medicine
Medicine & Public Health
Neoplasm Staging - methods
Nuclear Medicine
Oncology
Original Article
Orthopedics
Positron-Emission Tomography
Prognosis
Prospective Studies
Radiology
Radiopharmaceuticals
Tomography
Tomography, X-Ray Computed
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Summary:Purpose Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. Methods PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented. Results PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET ( p =0.001) and in the 28% of patients upstaged by PET to stage III or IV ( p =0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior. Conclusion PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-008-0958-z