Association of Myasthenia Gravis and Antisynthetase Syndrome: A Case Report

Myasthenia gravis is a chronic disease of neuromuscular transmission caused by loss of acetylcholine receptors. It can be found in association with other autoimmune disorders. We report the case of a 47-yr-old woman affected by Myasthenia gravis who complained of fever, progressive weakness of proxi...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2004-09, Vol.17 (3), p.395-399
Main Authors: Diaco, M., Ancarani, F., Montalto, M., Verrecchia, E., Evoli, A., Servidei, S., Gasbarrini, G., Manna, R.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Antibodies, Antinuclear - immunology
Arthritis - drug therapy
Arthritis - pathology
Autoimmune Diseases - complications
Autoimmune Diseases - drug therapy
Autoimmune Diseases - pathology
Female
Humans
Immunosuppressive Agents - therapeutic use
Ligases - immunology
Lung - pathology
Middle Aged
Myasthenia Gravis - complications
Myasthenia Gravis - drug therapy
Myasthenia Gravis - pathology
Polymyositis - complications
Polymyositis - drug therapy
Polymyositis - pathology
Raynaud Disease - drug therapy
Raynaud Disease - pathology
Respiratory Function Tests
Syndrome
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Summary:Myasthenia gravis is a chronic disease of neuromuscular transmission caused by loss of acetylcholine receptors. It can be found in association with other autoimmune disorders. We report the case of a 47-yr-old woman affected by Myasthenia gravis who complained of fever, progressive weakness of proximal limb muscle, arthritis, Raynaud's phenomenon and dyspnea. Chest X-rays and CT scan showed an interstitial lung disease; laboratory data indicated an inflammatory picture and increased serum muscle enzymes. Evaluation for infectious, metabolic, iatrogenic and neoplastic aetiologies was unrevealing. The patient's clinical condition together with positive results on antisynthetase antibody assay lead to the diagnosis of antisynthetase syndrome. To our knowledge, this is the first report on the association of Myasthenia gravis with antisynthetase syndrome.
ISSN:0394-6320
2058-7384
DOI:10.1177/039463200401700320