Neuronal Microcircuits: Frequency-Dependent Flow of Inhibition

New work suggests that feedback inhibition of neurons in the hippocampus is mediated by two distinct microcircuits. Interneurons targeting a neuron's soma are triggered by onset of activity, while those targeting distal dendrites are recruited by sustained activity. These circuits may thus conv...

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Bibliographic Details
Published in:Current biology 2004-10, Vol.14 (19), p.R837-R839
Main Authors: Mittmann, Wolfgang, Chadderton, Paul, Häusser, Michael
Format: Article
Language:English
Subjects:
Animals
Dendrites - physiology
Feedback, Physiological - physiology
Hippocampus - cytology
Hippocampus - physiology
Interneurons - physiology
Models, Neurological
Pyramidal Cells - physiology
Recruitment, Neurophysiological - physiology
Synaptic Transmission - physiology
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Summary:New work suggests that feedback inhibition of neurons in the hippocampus is mediated by two distinct microcircuits. Interneurons targeting a neuron's soma are triggered by onset of activity, while those targeting distal dendrites are recruited by sustained activity. These circuits may thus convey information about the timing and rate of activity, respectively.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2004.09.036