Changes in extracellular K+ concentration modulate properties of voltage dependent K+ channel conductance in PC-12 cells

The complex processing and integration of signals observed in neurons are facilitated by the diverse range of gating properties of the ion channels in this cell type, particularly the voltage-gated K+ channels (Kv). A distinctive combination of K+ channels endows neurons with a broad repertoire of e...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2004, Vol.50 (4), p.57-61
Main Authors: Boĭko, N Ia, Kucher, V V, Pohoriela, N Kh, Mahura, I S
Format: Article
Language:Ukrainian
Subjects:
Animals
Culture Media
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Membrane Potentials - drug effects
Membrane Potentials - physiology
Neurons - metabolism
Neurons - physiology
PC12 Cells
Potassium - metabolism
Potassium Channels, Voltage-Gated - metabolism
Potassium Channels, Voltage-Gated - physiology
Rats
Tetraethylammonium - pharmacology
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Summary:The complex processing and integration of signals observed in neurons are facilitated by the diverse range of gating properties of the ion channels in this cell type, particularly the voltage-gated K+ channels (Kv). A distinctive combination of K+ channels endows neurons with a broad repertoire of excitable properties and allows each neuron to respond in a specific manner to a given input at a given time. The properties of many K+ channels can be modulated by second messenger pathways activated by neurotransmitters and other stimuli. K+ channels are among the most frequent targets of the actions of several signalling systems.
ISSN:2522-9028