Down syndrome births in the United States from 1989 to 2001

We investigated the observed and expected Down syndrome livebirths in the US from 1989 to 2001. Using birth certificate data, we recorded maternal age-specific live births from 1989 to 2001, and stratified them by women 15 to 34 and 35 to 49 years old. We estimated Down syndrome live births from 198...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2004-09, Vol.191 (3), p.1044-1048
Main Authors: Egan, James F.X., Benn, Peter A., Zelop, Carolyn M., Bolnick, Alan, Gianferrari, Elisa, Borgida, Adam F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antenatal diagnosis
Biological and medical sciences
Chromosome aberrations
Down syndrome
Down Syndrome - epidemiology
Female
Gynecology. Andrology. Obstetrics
Humans
Livebirths
Maternal Age
Medical genetics
Medical sciences
Middle Aged
Pregnancy
Pregnancy, High-Risk
Trends
United States - epidemiology
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Summary:We investigated the observed and expected Down syndrome livebirths in the US from 1989 to 2001. Using birth certificate data, we recorded maternal age-specific live births from 1989 to 2001, and stratified them by women 15 to 34 and 35 to 49 years old. We estimated Down syndrome live births from 1989 to 2001, assuming no terminations. We recorded Down syndrome live births by year from 1989 to 2001. Despite an expected 1.32-fold increase in Down syndrome live birth rates from 1989 to 2001, Down syndrome live births actually declined. In 1989, the rate of Down syndrome cases was 15% lower than expected, decreasing to 51% by 1998. Women 15 to 34 had 45% fewer affected pregnancies in 2001, while women 35 to 49 had 53% fewer in 2001. We estimated that Down syndrome live births decreased from 3962 in 1989 to 3654 in 2001. Down syndrome live births declined in the US despite an expected increase caused by delayed or extended childbearing.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2004.06.050