Downstream process synthesis for biochemical production of butanol, ethanol, and acetone from grains: generation of optimal and near-optimal flowsheets with conventional operating units

Manufacturing butanol, ethanol, and acetone through grain fermentation has been attracting increasing research interest. In the production of these chemicals from fermentation, the cost of product recovery constitutes the major portion of the total production cost. Developing cost‐effective flowshee...

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Bibliographic Details
Published in:Biotechnology progress 2004, Vol.20 (5), p.1518-1527
Main Authors: Liu, J, Fan, L.T, Seib, P, Friedler, F, Bertok, B
Format: Article
Language:English
Subjects:
Acetone - economics
Acetone - metabolism
Algorithms
Biochemistry - economics
Biochemistry - methods
Biological and medical sciences
Bioreactors - economics
Bioreactors - microbiology
Biotechnology
Butanols - economics
Butanols - metabolism
Clostridium acetobutylicum - physiology
Computer Simulation
Edible Grain - economics
Edible Grain - microbiology
Ethanol - economics
Ethanol - metabolism
Fundamental and applied biological sciences. Psychology
Industrial Microbiology - economics
Industrial Microbiology - methods
Models, Biological
Models, Economic
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Summary:Manufacturing butanol, ethanol, and acetone through grain fermentation has been attracting increasing research interest. In the production of these chemicals from fermentation, the cost of product recovery constitutes the major portion of the total production cost. Developing cost‐effective flowsheets for the downstream processing is, therefore, crucial to enhancing the economic viability of this manufacturing method. The present work is concerned with the synthesis of such a process that minimizes the cost of the downstream processing. At the outset, a wide variety of processing equipment and unit operations, i.e., operating units, is selected for possible inclusion in the process. Subsequently, the exactly defined superstructure with minimal complexity, termed maximal structure, is constructed from these operating units with the rigorous and highly efficient graph‐theoretic method for process synthesis based on process graphs (P‐graphs). Finally, the optimal and near‐optimal flowsheets in terms of cost are identified.
ISSN:8756-7938
1520-6033
DOI:10.1021/bp049845v