Functional and morphological cardiac changes in myeloproliferative disorders (clinical study)

Purpose: Cardiac involvement is not well defined in myeloproliferative disorders (MPD). The purpose of this study was to evaluate the cardiac involvement by transthoracic echocardiography in MPD. Materials and methods: The study groups were 36 patients (mean age: 58±15 years, 20 female and 16 male)...

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Bibliographic Details
Published in:International journal of cardiology 2004-11, Vol.97 (2), p.213-220
Main Authors: Kadikoylu, Gurhan, Onbasili, Alper, Tekten, Tarkan, Barutca, Sabri, Bolaman, Zahit
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiac lesions
Cardiology. Vascular system
Case-Control Studies
Echocardiography
Female
Heart Valve Diseases - diagnostic imaging
Heart Valve Diseases - etiology
Heart Valves - diagnostic imaging
Heart Valves - pathology
Heart Valves - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Hypertension, Pulmonary - etiology
Male
Medical sciences
Middle Aged
Myeloproliferative disorders
Myeloproliferative Disorders - complications
Myeloproliferative Disorders - diagnostic imaging
Thrombocytosis - etiology
Thromboembolism - etiology
Ultrasonography
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Summary:Purpose: Cardiac involvement is not well defined in myeloproliferative disorders (MPD). The purpose of this study was to evaluate the cardiac involvement by transthoracic echocardiography in MPD. Materials and methods: The study groups were 36 patients (mean age: 58±15 years, 20 female and 16 male) with MPD and 30 age-matched healthy controls. MPD group included 15 essential thrombocythemia (ET), eight chronic phase chronic myelogenous leukemia (CML), seven idiopathic myelofibrosis (MF) and six polcythemia vera patients. Results: Valvular regurgitations were present in 14 patients (39%) and eight controls (27%), ( P>0.05). Mitral regurgitation (MR) was more prominent in CML compared to controls ( P=0.044). The rates of annular calcifications, valvular thickening, and vegetation like lesions were not different between MPD and control groups. Pulmonary hypertension (PHT) was present in six (17%) patients, but none of the controls ( P=0.021). The rates of PHT in CML and MF were significantly higher than controls ( P
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2003.08.013