The INO80 chromatin remodeling complex in transcription, replication and repair

The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantial...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2009-02, Vol.34 (2), p.71-77
Main Authors: Conaway, Ronald C., Conaway, Joan Weliky
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - genetics
Adenosine Triphosphatases - metabolism
Animals
Chromatin - metabolism
Chromatin Assembly and Disassembly - genetics
DNA Repair
DNA Replication
Humans
Models, Biological
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Transcription, Genetic
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Summary:The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2008.10.010