Peripheral blood flow cytometry based diagnosis in primary cutaneous aggressive epidermotropic CD8+ T‐cell lymphoma: Implications for more extensive use

Primary cutaneous epidermotropic CD8‐positive T‐cell lymphoma represents an aggressive form of T‐cell cutaneous lymphomas. Diagnosis is based on biopsies obtained from skin lesions. Here, we would like to report a case diagnosed by using flow cytometry performed on peripheral blood mononuclear cells...

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Bibliographic Details
Published in:Cytometry. Part B, Clinical cytometry Clinical cytometry, 2009-03, Vol.76B (2), p.102-106
Main Authors: Benetatos, Leonidas, Dova, Lefkothea, Baxevanos, Gerasimos, Kolaitis, Nikolaos I., Bourantas, Konstantinos L., Vartholomatos, Georgios
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antibodies
Bcl‐2
Biomarkers - analysis
Biomarkers - blood
CD8 Antigens - analysis
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - pathology
cutaneous aggressive epidermotropic CD8+ T‐cell lymphoma
Diagnosis, Differential
Disease Progression
Epidermis - immunology
Epidermis - pathology
Epidermis - physiopathology
Fatal Outcome
flow cytometry
Flow Cytometry - methods
Humans
Immunophenotyping - methods
Lymphoma, T-Cell, Cutaneous - diagnosis
Lymphoma, T-Cell, Cutaneous - immunology
Lymphoma, T-Cell, Cutaneous - physiopathology
Male
Neoplasm Invasiveness - diagnosis
Neoplasm Invasiveness - immunology
Neoplasm Invasiveness - physiopathology
Predictive Value of Tests
Prognosis
Skin - immunology
Skin - pathology
Skin - physiopathology
Skin Diseases - diagnosis
Skin Diseases - immunology
Skin Diseases - physiopathology
Tregs
UCH‐T4+‐SK1
ZAP‐70
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Description
Summary:Primary cutaneous epidermotropic CD8‐positive T‐cell lymphoma represents an aggressive form of T‐cell cutaneous lymphomas. Diagnosis is based on biopsies obtained from skin lesions. Here, we would like to report a case diagnosed by using flow cytometry performed on peripheral blood mononuclear cells. Moreover, an important finding was the difference in the results on targeting the CD8 antigen by using two different commercially available monoclonal antibodies. Perhaps, more than one antibody should be used in primary cutaneous aggressive epidermotropic CD8‐positive T‐cell lymphomas, in orderto be more accurate in the diagnosis and so in the classification of such diseases. © 2008 Clinical Cytometry Society
ISSN:1552-4949
1552-4957
DOI:10.1002/cyto.b.20447