Dendritic cell sarcomas/tumours of the breast: report of two cases

Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2009-03, Vol.454 (3), p.333-339
Main Authors: Kapucuoglu, Nilgun, Percinel, Sıbel, Ventura, Terenzio, Lang, RongGang, Al-Daraji, Wael, Eusebi, Vincenzo
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD - biosynthesis
Antigens, Differentiation, Myelomonocytic - biosynthesis
Biological and medical sciences
Biomarkers, Tumor - analysis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Case Report
Dendritic Cell Sarcoma, Follicular - metabolism
Dendritic Cell Sarcoma, Follicular - pathology
Dendritic Cell Sarcoma, Follicular - surgery
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lesions
Leukocyte Common Antigens - biosynthesis
Mastectomy
Medical sciences
Medicine
Medicine & Public Health
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Receptors, Complement 3d - biosynthesis
S100 Proteins - biosynthesis
Sarcoma
Tumors
Vimentin - biosynthesis
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Summary:Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year-old woman who both showed a firm lump in the left breast. The FDCS/T lesion superficially appeared as an anaplastic carcinoma and the IDCS/T was reminiscent of a spindle cell sarcomatoid carcinoma. Nevertheless both lesions were negative for keratins while case 1 displayed neoplastic cells strongly positive for CD21, vimentin and focally for CD68 and S-100 protein. The tumour cells of case 2 were positive for S-100, CD68 and CD45. In breast, an unusual keratin negative tumour composed predominantly of spindle cells arranged in fascicles, storiform pattern or whorls with a lymphoid rich stroma should raise suspicion for FDCS/Ts or IDCS/Ts. The distinction from malignant tumours with similar features is discussed.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-009-0729-7