The effectiveness of transdermal electromotive administration with verapamil and dexamethasone in the treatment of Peyronie’s disease

• Published in: International urology and nephrology 2009, Vol.41 (1), p.113-118
• Main Authors: Tuygun, Can, Ozok, Ugur Hakkı, Gucuk, Adnan, Halil Bozkurt, I., Abdurrahim Imamoglu, M.
• Format: Article
• Language: English
• Subjects: Administration, Cutaneous; Adult; Aged; Anti-Inflammatory Agents - administration & dosage; Calcium Channel Blockers - administration & dosage; Dexamethasone - administration & dosage; Electrochemotherapy; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Penile Induration - drug therapy; Prospective Studies; Urology; Urology - Original Paper; Verapamil - administration & dosage
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-008-9408-x

Aim To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie’s disease (PD). Method Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examination, photographs, and penile USG, before and after therapy. All patients were treated with TEA of the combination of verapamil and dexamethasone. The treatment plan included a total of 20 sessions (at 3-day intervals for a period of 2 months), each with a duration of 20 min. At the end of the study, improvements in penile plaques, penile deviation, pain on erection, and erectile dysfunction were determined. Results The findings in 41 of the 51 patients were eligible to present. Median patient age was 52 years. Median duration of disease at presentation was 8 months. Remarkable reduction in palpable plaques and in penile angulation was observed in 10 patients (24%) and 11 (26%) patients, respectively. There were significant decreases in median plaque volume from 72 mm 2 to 45 mm 2 ( P