Expression of Fibroblast growth factor 19 ( Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse

The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic ex...

Full description

Saved in:
Bibliographic Details
Published in:Gene Expression Patterns 2004-10, Vol.4 (6), p.687-693
Main Authors: Kurose, Hitomi, Bito, Takaaki, Adachi, Taro, Shimizu, Miyuki, Noji, Sumihare, Ohuchi, Hideyo
Format: Article
Language:English
Subjects:
Animals
Chick Embryo
Chicken
Cranial placodes
DNA Primers - chemistry
DNA, Complementary - metabolism
Embryogenesis
Eye - embryology
Eye development
FGF15
FGF19
Fibroblast growth factor
Fibroblast Growth Factors - biosynthesis
In Situ Hybridization
Lens
Lens, Crystalline - embryology
Ligands
Mice
Microscopy, Confocal
Microscopy, Fluorescence
Molecular Sequence Data
Mouse
Retina
Retina - embryology
Retinal horizontal cell
Species Specificity
Time Factors
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic expression patterns for Fgf19 in the optic vesicle, lens primordia and retinal horizontal cells. Overall expression pattern of Fgf19 during chicken embryogenesis was also examined: Fgf19 is expressed in the regions associated with cranial placodes induction, boundary regions of rhombomeres, somites, specific groups of neural cells in midbrain, hindbrain, and those derived from epibranchial placodes, and the apical ectodermal ridge of limb buds. Expression pattern of the Fgf19–orthologous gene Fgf15 was further examined in the mouse developing eye. Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis.
ISSN:1567-133X
1872-7298
DOI:10.1016/j.modgep.2004.04.005