DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract

Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in XRCC2 and XRCC3 genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated the effect of XR...

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Bibliographic Details
Published in:International journal of cancer 2004-12, Vol.112 (5), p.901-904
Main Authors: Benhamou, Simone, Tuimala, Jarno, Bouchardy, Christine, Dayer, Pierre, Sarasin, Alain, Hirvonen, Ari
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
cancers of the upper aerodigestive tract
Case-Control Studies
DNA Damage
DNA Repair
DNA repair gene polymorphisms
DNA-Binding Proteins - genetics
epidemiology
Female
Genetic Predisposition to Disease
Humans
Male
Medical sciences
Middle Aged
Mouth Neoplasms - etiology
Otorhinolaryngology. Stomatology
Pharyngeal Neoplasms - etiology
Polymorphism, Genetic
Reactive Oxygen Species
smoking
Smoking - adverse effects
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
XRCC2, XRCC3
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Summary:Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in XRCC2 and XRCC3 genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated the effect of XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms in cancer proneness in 121 oral/pharynx cancer cases, 129 larynx cancer cases and 172 noncancer controls, all Caucasian smokers. The XRCC2 His‐allele was associated with a significantly increased risk of pharyngeal cancer (OR=2.9, 95% CI: 1.3–6.2). No significant associations were observed between the XRCC3 Thr241Met polymorphism and overall risk of developing UADT cancers. However, quite opposite to the expectations, a reduced risk of supraglottic cancer was found for carriers of the XRCC3 Met variant allele (OR=0.3, 95% CI: 0.2–0.7). These findings provide evidence for the view that polymorphisms in DNA repair genes may modify individual susceptibility to smoking‐related cancers. © 2004 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.20474