Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients

• Published in: Neurobiology of aging 2004-11, Vol.25 (10), p.1299-1303
• Main Authors: Walter, Anna, Korth, Ulrike, Hilgert, Michael, Hartmann, Joachim, Weichel, Oksana, Hilgert, Marion, Fassbender, Klaus, Schmitt, Andrea, Klein, Jochen
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging - cerebrospinal fluid; Alzheimer Disease - cerebrospinal fluid; Alzheimer’s disease; Biological and medical sciences; Biomarkers - cerebrospinal fluid; Cerebrospinal fluid; Choline; Choline - cerebrospinal fluid; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia, Vascular - cerebrospinal fluid; Female; Glycerophosphocholine; Glycerylphosphorylcholine - cerebrospinal fluid; Humans; Male; Medical sciences; Middle Aged; Neurology; Phosphocholine; Phospholipase A 2; Phosphorylcholine - cerebrospinal fluid
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2004.02.016

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF). Among 30 cognitively normal patients the average CSF levels of GPCh, phosphocholine and choline were 3.64, 1.28, and 1.93 μM, respectively; metabolite levels did not change with increasing age. When compared with age-matched controls, patients with Alzheimer’s disease had elevated levels of all choline metabolites: GPCh was significantly increased by 76% ( P