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Using a kinase screen to investigate the constituents of the sponge Stelletta clavosa obtained from diverse habitats
[Display omitted] Fourteen collections of the marine sponge Stelletta clavosa have been obtained from diverse Indo-Pacific locations in order to conduct a comparison of their major constituents. The dichloromethane extract of one collection (no. 00369) exhibited activity in a c-Raf-1 kinase assay. B...
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Published in: | Bioorganic & medicinal chemistry 2004-11, Vol.12 (21), p.5631-5637 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
Fourteen collections of the marine sponge
Stelletta clavosa have been obtained from diverse Indo-Pacific locations in order to conduct a comparison of their major constituents. The dichloromethane extract of one collection (no. 00369) exhibited activity in a c-Raf-1 kinase assay. Bioactivity-directed isolation resulted in the known porphyrin analogs pyropheophorbide
a (
2) and purpurin 18 methyl ester (
3). Further spectroscopic screening of the various sponge extracts resulted in the isolation of four swinholide polyketides, a carotenoid, and three diketopiperazines. Pyropheophorbide
a (
2) exhibited the best IC
50 among the porphyrin type compounds (IC
50 |
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ISSN: | 0968-0896 1464-3391 |
DOI: | 10.1016/j.bmc.2004.07.061 |