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Using a kinase screen to investigate the constituents of the sponge Stelletta clavosa obtained from diverse habitats

[Display omitted] Fourteen collections of the marine sponge Stelletta clavosa have been obtained from diverse Indo-Pacific locations in order to conduct a comparison of their major constituents. The dichloromethane extract of one collection (no. 00369) exhibited activity in a c-Raf-1 kinase assay. B...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2004-11, Vol.12 (21), p.5631-5637
Main Authors: Wegerski, Christopher J., France, Dennis, Cornell-Kennon, Susan, Crews, Phillip
Format: Article
Language:English
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Summary:[Display omitted] Fourteen collections of the marine sponge Stelletta clavosa have been obtained from diverse Indo-Pacific locations in order to conduct a comparison of their major constituents. The dichloromethane extract of one collection (no. 00369) exhibited activity in a c-Raf-1 kinase assay. Bioactivity-directed isolation resulted in the known porphyrin analogs pyropheophorbide a ( 2) and purpurin 18 methyl ester ( 3). Further spectroscopic screening of the various sponge extracts resulted in the isolation of four swinholide polyketides, a carotenoid, and three diketopiperazines. Pyropheophorbide a ( 2) exhibited the best IC 50 among the porphyrin type compounds (IC 50
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2004.07.061