Chemoattractant signaling in dictyostelium discoideum

Dictyostelium is an accessible organism for studies of signaling via chemoattractant receptors. Chemoattractant-mediated signaling events and components are reviewed and presented as a series of connected modules, including excitation, inhibition, G protein-independent responses, early gene expressi...

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Bibliographic Details
Published in:Annual review of cell and developmental biology 2004-01, Vol.20 (1), p.223-253
Main Authors: Manahan, Carol L, Iglesias, Pablo A, Long, Yu, Devreotes, Peter N
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Cell Communication - physiology
Chemotactic Factors - metabolism
Cyclic AMP - metabolism
Dictyostelium - metabolism
Dictyostelium discoideum
Gene Expression Regulation
GTP-Binding Proteins - metabolism
Myosins - metabolism
Phosphatidylinositols - metabolism
Phosphatidylinositols - physiology
Protozoan Proteins - chemistry
Protozoan Proteins - metabolism
Pseudopodia - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
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Summary:Dictyostelium is an accessible organism for studies of signaling via chemoattractant receptors. Chemoattractant-mediated signaling events and components are reviewed and presented as a series of connected modules, including excitation, inhibition, G protein-independent responses, early gene expression, inositol lipids, PH domain-containing proteins, cyclic AMP signaling, polarization acquisition, actin polymerization, and cortical myosin. The network incorporates information from biochemical, genetic, and cell biological experiments carried out on living cells. The modules and connections represent current understanding, and future information is expected to modify and build upon this structure.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev.cellbio.20.011303.132633