Manipulating dendritic cell biology for the active immunotherapy of cancer

Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have an unequaled capacity to initiate primary immune responses, including tolerogenic responses. Because of the importance of DCs in the induction and control of immunity, an understanding of their biology is central to the...

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Bibliographic Details
Published in:Blood 2004-10, Vol.104 (8), p.2235-2246
Main Authors: O'Neill, David W., Adams, Sylvia, Bhardwaj, Nina
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Humans
Immune Tolerance
Immunotherapy
Immunotherapy, Active
Medical sciences
Neoplasms - immunology
Neoplasms - therapy
Pharmacology. Drug treatments
Vaccines - immunology
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Summary:Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have an unequaled capacity to initiate primary immune responses, including tolerogenic responses. Because of the importance of DCs in the induction and control of immunity, an understanding of their biology is central to the development of potent immunotherapies for cancer, chronic infections, autoimmune disease, and induction of transplantation tolerance. This review discusses recent advances in DC research and the application of this knowledge toward new strategies for the clinical manipulation of DCs for cancer immunotherapy.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2003-12-4392