Total Synthesis of Azithromycin

The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl₂ c...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (10), p.1827-1829
Main Authors: Kim, Hyoung Cheul, Kang, Sung Ho
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
asymmetric synthesis
Azithromycin - chemical synthesis
Azithromycin - chemistry
Catalysis
Copper - chemistry
desymmetrization
Erythromycin - chemistry
Imines - chemistry
natural products
Stereoisomerism
substituted glycerols
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl₂ catalyst.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200805334