Management of undifferentiated sarcoma of the liver including living donor liver transplantation as a backup procedure

Abstract We present the cases of 3 children with huge undifferentiated sarcoma of the liver who were treated with surgical excision including liver transplantation as an option and adjuvant chemotherapy. All 3 patients were males aged 10, 13, and 15 years old. The size of the tumor was 10, 15, and 2...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2009-02, Vol.44 (2), p.e33-e38
Main Authors: Okajima, Hideaki, Ohya, Yuki, Lee, Kwang-Jong, Yamamoto, Hidekazu, Asonuma, Katsuhiro, Nagaoki, Yuko, Ohama, Kazunori, Korogi, Masahiko, Anan, Tadashi, Hashiyama, Motohiro, Endo, Fumio, Iyama, Kenichi, Inomata, Yukihiro
Format: Article
Language:English
Subjects:
Adolescent
Child
Humans
Liver Neoplasms - surgery
Liver Transplantation
Living donor liver transplantation
Living Donors
Male
Pediatrics
Sarcoma - surgery
Surgery
Undifferentiated sarcoma of the liver
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract We present the cases of 3 children with huge undifferentiated sarcoma of the liver who were treated with surgical excision including liver transplantation as an option and adjuvant chemotherapy. All 3 patients were males aged 10, 13, and 15 years old. The size of the tumor was 10, 15, and 20 cm in diameter, respectively. The youngest patient is disease free and doing well 43 months after resection. The 13-year-old patient presented with tumor rupture and underwent operation. The primary tumor and the ruptured tissue fragments were removed and he was given postoperative chemotherapy. The patient is disease free and doing well 52 months after surgery. The oldest patient had an unresectable tumor in the hilar region. Preoperative chemotherapy was given but later discontinued owing to severe side effects. He underwent living donor liver transplantation followed by postoperative chemotherapy. The patient had recurrent tumor 24 months after transplantation that was excised at reoperation. He is doing well and is disease free 18 months after the second procedure. Complete removal of the tumor including total hepatectomy and transplantation when indicated and suitable pre- and/or postoperative chemotherapy is an effective treatment for children with undifferentiated sarcoma of the liver.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2008.11.046