Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion

Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem that can result in cardiac injury and (or) heart failure. The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myoc...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2009-02, Vol.87 (2), p.137-142
Main Authors: ONDREJCAKOVA, Maria, RAVINGEROVA, Tatiana, BAKOS, Jan, PANCZA, Dezider, JEZOVA, Daniela
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology
Cardiovascular Agents - pharmacology
Cardiovascular disease
Cardiovascular system
Coronary Circulation - drug effects
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Health aspects
Heart Rate - drug effects
Hormones
In Vitro Techniques
Male
Myocardial Contraction - drug effects
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocardial Infarction - prevention & control
Myocardial ischemia
Myocardial Reperfusion Injury - pathology
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Myocardium - pathology
Oxytocin
Oxytocin - pharmacology
Pathology
Peptides
Perfusion
Prevention
Rats
Rats, Wistar
Reperfusion injury
Studies
Time Factors
Ventricular Function, Left - drug effects
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem that can result in cardiac injury and (or) heart failure. The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myocardial damage. The functional parameters of isolated Langendorff-perfused rat hearts were recorded before and after global 25 min ischemia and subsequent reperfusion. The infarct size was determined by a computerized planimetric method. The results showed that oxytocin produced negative chronotropic effect even at low concentrations (90-125 nmol/L). Perfusion with oxytocin before ischemia resulted in significant reduction of the infarct size (p
ISSN:0008-4212
1205-7541
DOI:10.1139/Y08-108