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Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion
Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem that can result in cardiac injury and (or) heart failure. The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myoc...
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| Published in: | Canadian journal of physiology and pharmacology 2009-02, Vol.87 (2), p.137-142 |
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| container_end_page | 142 |
| container_issue | 2 |
| container_start_page | 137 |
| container_title | Canadian journal of physiology and pharmacology |
| container_volume | 87 |
| creator | ONDREJCAKOVA, Maria RAVINGEROVA, Tatiana BAKOS, Jan PANCZA, Dezider JEZOVA, Daniela |
| description | Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem that can result in cardiac injury and (or) heart failure. The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myocardial damage. The functional parameters of isolated Langendorff-perfused rat hearts were recorded before and after global 25 min ischemia and subsequent reperfusion. The infarct size was determined by a computerized planimetric method. The results showed that oxytocin produced negative chronotropic effect even at low concentrations (90-125 nmol/L). Perfusion with oxytocin before ischemia resulted in significant reduction of the infarct size (p |
| doi_str_mv | 10.1139/Y08-108 |
| format | article |
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The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myocardial damage. The functional parameters of isolated Langendorff-perfused rat hearts were recorded before and after global 25 min ischemia and subsequent reperfusion. The infarct size was determined by a computerized planimetric method. The results showed that oxytocin produced negative chronotropic effect even at low concentrations (90-125 nmol/L). Perfusion with oxytocin before ischemia resulted in significant reduction of the infarct size (p<0.01), which was about 66% smaller than that in the control group. To evaluate the functional mechanisms involved, further experiments were performed under conditions of constant heart rate. The lower dose of oxytocin (90 nmol/L), which was ineffective in spontaneously beating hearts, induced a significant decrease of contractility. Elimination of the negative chronotropic effect of oxytocin prevented its cardioprotective action. In conclusion, our results demonstrated an attenuation of the infarct size in oxytocin-treated hearts, indicating a cardioprotective effect of oxytocin. The data suggest that the negative chronotropic action of oxytocin participates in its protective effects on ischemia-reperfusion-induced myocardial injury.</description><identifier>ISSN: 0008-4212</identifier><identifier>EISSN: 1205-7541</identifier><identifier>DOI: 10.1139/Y08-108</identifier><identifier>PMID: 19234577</identifier><identifier>CODEN: CJPPA3</identifier><language>eng</language><publisher>Plattsburgh, NY: National Research Council of Canada</publisher><subject>Animals ; Biological and medical sciences ; Cardiology ; Cardiovascular Agents - pharmacology ; Cardiovascular disease ; Cardiovascular system ; Coronary Circulation - drug effects ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Health aspects ; Heart Rate - drug effects ; Hormones ; In Vitro Techniques ; Male ; Myocardial Contraction - drug effects ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardial Infarction - prevention & control ; Myocardial ischemia ; Myocardial Reperfusion Injury - pathology ; Myocardial Reperfusion Injury - physiopathology ; Myocardial Reperfusion Injury - prevention & control ; Myocardium - pathology ; Oxytocin ; Oxytocin - pharmacology ; Pathology ; Peptides ; Perfusion ; Prevention ; Rats ; Rats, Wistar ; Reperfusion injury ; Studies ; Time Factors ; Ventricular Function, Left - drug effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Canadian journal of physiology and pharmacology, 2009-02, Vol.87 (2), p.137-142</ispartof><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 NRC Research Press</rights><rights>Copyright National Research Council of Canada Feb 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21458424$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19234577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ONDREJCAKOVA, Maria</creatorcontrib><creatorcontrib>RAVINGEROVA, Tatiana</creatorcontrib><creatorcontrib>BAKOS, Jan</creatorcontrib><creatorcontrib>PANCZA, Dezider</creatorcontrib><creatorcontrib>JEZOVA, Daniela</creatorcontrib><title>Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion</title><title>Canadian journal of physiology and pharmacology</title><addtitle>Can J Physiol Pharmacol</addtitle><description>Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem that can result in cardiac injury and (or) heart failure. The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myocardial damage. The functional parameters of isolated Langendorff-perfused rat hearts were recorded before and after global 25 min ischemia and subsequent reperfusion. The infarct size was determined by a computerized planimetric method. The results showed that oxytocin produced negative chronotropic effect even at low concentrations (90-125 nmol/L). Perfusion with oxytocin before ischemia resulted in significant reduction of the infarct size (p<0.01), which was about 66% smaller than that in the control group. To evaluate the functional mechanisms involved, further experiments were performed under conditions of constant heart rate. The lower dose of oxytocin (90 nmol/L), which was ineffective in spontaneously beating hearts, induced a significant decrease of contractility. Elimination of the negative chronotropic effect of oxytocin prevented its cardioprotective action. In conclusion, our results demonstrated an attenuation of the infarct size in oxytocin-treated hearts, indicating a cardioprotective effect of oxytocin. The data suggest that the negative chronotropic action of oxytocin participates in its protective effects on ischemia-reperfusion-induced myocardial injury.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiovascular Agents - pharmacology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Coronary Circulation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>Heart Rate - drug effects</subject><subject>Hormones</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - prevention & control</subject><subject>Myocardial ischemia</subject><subject>Myocardial Reperfusion Injury - pathology</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Myocardium - pathology</subject><subject>Oxytocin</subject><subject>Oxytocin - pharmacology</subject><subject>Pathology</subject><subject>Peptides</subject><subject>Perfusion</subject><subject>Prevention</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion injury</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0008-4212</issn><issn>1205-7541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqVkl1rFDEUhoNY7FrFfyCDUMGLqfmameSyFG0LpQU_LrwaMsnJmmUm2SaZsvvvTemqXemN5OKcvHnOm5NDEHpD8AkhTH78gUVNsHiGFoTipu4aTp6jBcZF5pTQQ_QypVXZtoKJF-iQSMp403ULZG422xy08xVsIOZUrWPIoLO7gwqsLVmqgq_K-Z3LMVTTNmgVjVNj0VZz3JZgZg2mGkqa9E-YnKqUN1WENUQ7Jxf8K3Rg1Zjg9S4eoe-fP307u6ivbs4vz06v6iVnItcDBoZpg7kZQLP726UVHeu4wi23QtpWtMQM3OoOG9qAIbLUNbSVWtFBEnaE3j_4lkfczpByP5WWYByVhzCnvm0ll41gBXz3D7gKc_Slt55S0tFiSgtUP0BLNULvvA05Kr0ED1GNwYN1RT6lmAkpOKF_Tfd4vXa3_WPo5AmoLFMGp590_bBXUJgMm7xUc0r95dcv_8Fe77NvdyOYhwlMv45uUnHb__4aBTjeASppNdqovHbpD0cJbwSnnP0CLPjDAw</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>ONDREJCAKOVA, Maria</creator><creator>RAVINGEROVA, Tatiana</creator><creator>BAKOS, Jan</creator><creator>PANCZA, Dezider</creator><creator>JEZOVA, Daniela</creator><general>National Research Council of Canada</general><general>NRC Research Press</general><general>Canadian Science Publishing NRC Research Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>ISN</scope><scope>ISR</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion</title><author>ONDREJCAKOVA, Maria ; RAVINGEROVA, Tatiana ; BAKOS, Jan ; PANCZA, Dezider ; JEZOVA, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g438t-b0e302504dbec3effe9f87374a064f89f6861db4fc70d25ed194385269ca2b913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiovascular Agents - pharmacology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>Coronary Circulation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>Heart Rate - drug effects</topic><topic>Hormones</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - prevention & control</topic><topic>Myocardial ischemia</topic><topic>Myocardial Reperfusion Injury - pathology</topic><topic>Myocardial Reperfusion Injury - physiopathology</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Myocardium - pathology</topic><topic>Oxytocin</topic><topic>Oxytocin - pharmacology</topic><topic>Pathology</topic><topic>Peptides</topic><topic>Perfusion</topic><topic>Prevention</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion injury</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ONDREJCAKOVA, Maria</creatorcontrib><creatorcontrib>RAVINGEROVA, Tatiana</creatorcontrib><creatorcontrib>BAKOS, Jan</creatorcontrib><creatorcontrib>PANCZA, Dezider</creatorcontrib><creatorcontrib>JEZOVA, Daniela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: Canada</collection><collection>Science (Gale in Context)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of physiology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ONDREJCAKOVA, Maria</au><au>RAVINGEROVA, Tatiana</au><au>BAKOS, Jan</au><au>PANCZA, Dezider</au><au>JEZOVA, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion</atitle><jtitle>Canadian journal of physiology and pharmacology</jtitle><addtitle>Can J Physiol Pharmacol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>87</volume><issue>2</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>0008-4212</issn><eissn>1205-7541</eissn><coden>CJPPA3</coden><abstract>Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem that can result in cardiac injury and (or) heart failure. The aim of the present study was to test the hypothesis that neuropeptide oxytocin induces cardioprotective effects on ischemia-reperfusion-induced myocardial damage. The functional parameters of isolated Langendorff-perfused rat hearts were recorded before and after global 25 min ischemia and subsequent reperfusion. The infarct size was determined by a computerized planimetric method. The results showed that oxytocin produced negative chronotropic effect even at low concentrations (90-125 nmol/L). Perfusion with oxytocin before ischemia resulted in significant reduction of the infarct size (p<0.01), which was about 66% smaller than that in the control group. To evaluate the functional mechanisms involved, further experiments were performed under conditions of constant heart rate. The lower dose of oxytocin (90 nmol/L), which was ineffective in spontaneously beating hearts, induced a significant decrease of contractility. Elimination of the negative chronotropic effect of oxytocin prevented its cardioprotective action. In conclusion, our results demonstrated an attenuation of the infarct size in oxytocin-treated hearts, indicating a cardioprotective effect of oxytocin. The data suggest that the negative chronotropic action of oxytocin participates in its protective effects on ischemia-reperfusion-induced myocardial injury.</abstract><cop>Plattsburgh, NY</cop><pub>National Research Council of Canada</pub><pmid>19234577</pmid><doi>10.1139/Y08-108</doi><tpages>6</tpages></addata></record> |
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| ispartof | Canadian journal of physiology and pharmacology, 2009-02, Vol.87 (2), p.137-142 |
| issn | 0008-4212 1205-7541 |
| language | eng |
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| source | SPORTDiscus with Full Text |
| subjects | Animals Biological and medical sciences Cardiology Cardiovascular Agents - pharmacology Cardiovascular disease Cardiovascular system Coronary Circulation - drug effects Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Health aspects Heart Rate - drug effects Hormones In Vitro Techniques Male Myocardial Contraction - drug effects Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial ischemia Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - pathology Oxytocin Oxytocin - pharmacology Pathology Peptides Perfusion Prevention Rats Rats, Wistar Reperfusion injury Studies Time Factors Ventricular Function, Left - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion |
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