Desmoplastic infantile ganglioglioma -- a case report

Desmoplastic infantile ganglioglioma is a very rare supratentorial tumor occurring in the first two years of life. A five-month-old female infant presented with recurrent seizures, large head and loss of acquired milestones. Computerized Tomographic Scan of brain showed a large subarachnoid cyst wit...

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Bibliographic Details
Published in:Neurology India 2004-09, Vol.52 (3), p.384-386
Main Authors: Balasubramanian, D, Ramesh, V G, Deiveegan, K, Ghosh, Mitra, Mallikarjuna, V S, Annapoorneswari, T P, Chidambaranathan, N, Ramani, K V N
Format: Article
Language:English
Subjects:
Astrocytes - pathology
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Brain tumors
Care and treatment
Diseases
Female
Ganglioglioma - diagnostic imaging
Ganglioglioma - pathology
Humans
Infant
Infants (Newborn)
Neurosurgical Procedures
Seizures - etiology
Tomography, X-Ray Computed
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Summary:Desmoplastic infantile ganglioglioma is a very rare supratentorial tumor occurring in the first two years of life. A five-month-old female infant presented with recurrent seizures, large head and loss of acquired milestones. Computerized Tomographic Scan of brain showed a large subarachnoid cyst with a solid intensely contrast enhancing tumor in the right temporoparietal region with severe degree of mass effect. Craniotomy and total excision of the tumor followed subsequently by subduro-peritoneal shunt for the extracerebral fluid collection was done. The child made good recovery. Histopathology revealed features of desmoplastic infantile ganglioglioma, viz., marked desmoplastic component with glial and neuronal elements. Immunohistochemistry showed positive staining for glial fibrillary acidic protein (GFAP) with areas of synaptophysin and chromogranin positivity. Desmoplastic infantile ganglioglioma is a rare tumor of infancy, which has excellent prognosis after total excision. No adjuvant therapy is required. This is the first Indian report of desmoplastic infantile ganglioglioma out of less than fifty cases reported worldwide.
ISSN:0028-3886
1998-4022