Functional analysis of muscarinic acetylcholine receptors using knockout mice

Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mACh...

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Bibliographic Details
Published in:Life sciences (1973) 2004-11, Vol.75 (25), p.2971-2981
Main Authors: Matsui, Minoru, Yamada, Shizuo, Oki, Tomomi, Manabe, Toshiya, Taketo, Makoto M., Ehlert, Frederick J.
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - etiology
Animals
Catalepsy
Knockout mice
Learning
Memory
Mice
Mice, Knockout
Muscarinic acetylcholine receptor
Muscle, Smooth - physiology
Parasympathetic nervous system
Receptors, Muscarinic - classification
Receptors, Muscarinic - physiology
Salivation
Smooth muscle contraction
Tissue distribution
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Description
Summary:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO mice). The systematic analyses of these mice have been useful in revealing the functional difference among mAChR subtypes. Here, we review our prior research on these mutant mice and also some notable findings reported by other research groups.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2004.05.034