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Functional analysis of muscarinic acetylcholine receptors using knockout mice
Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mACh...
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| Published in: | Life sciences (1973) 2004-11, Vol.75 (25), p.2971-2981 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c446t-fa00d38bcdd575d013e41aaa3e3ef2a718f81b4b4a4acf9e119406ecfc31fb2e3 |
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| cites | cdi_FETCH-LOGICAL-c446t-fa00d38bcdd575d013e41aaa3e3ef2a718f81b4b4a4acf9e119406ecfc31fb2e3 |
| container_end_page | 2981 |
| container_issue | 25 |
| container_start_page | 2971 |
| container_title | Life sciences (1973) |
| container_volume | 75 |
| creator | Matsui, Minoru Yamada, Shizuo Oki, Tomomi Manabe, Toshiya Taketo, Makoto M. Ehlert, Frederick J. |
| description | Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO mice). The systematic analyses of these mice have been useful in revealing the functional difference among mAChR subtypes. Here, we review our prior research on these mutant mice and also some notable findings reported by other research groups. |
| doi_str_mv | 10.1016/j.lfs.2004.05.034 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2004-11, Vol.75 (25), p.2971-2981 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66954339 |
| source | ScienceDirect Journals |
| subjects | Abnormalities, Multiple - etiology Animals Catalepsy Knockout mice Learning Memory Mice Mice, Knockout Muscarinic acetylcholine receptor Muscle, Smooth - physiology Parasympathetic nervous system Receptors, Muscarinic - classification Receptors, Muscarinic - physiology Salivation Smooth muscle contraction Tissue distribution |
| title | Functional analysis of muscarinic acetylcholine receptors using knockout mice |
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